Testosterone Therapy After Lupron? - Advanced Prostate...

Advanced Prostate Cancer
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Testosterone Therapy After Lupron?


April 2016 Robotic Surgery, June 2017 Casodex/Lurpon, October 2017 Proton Radiation, January 2018 Chemo (4X). I continued Lupron from June 17 through January 2019. Stopped Lupron due to side effects January 20 this year. Currently no treatment, Q30 Day ultra-sensisitve PSA & T level - PSA undetectable, T Level 12 in February & 14 in March. QUESTION: Both oncologist and urologist suggest considering Testosterone therapy. Any feedback appreciated!

12 Replies

Alternating Lupron and Testosterone (called Bipolar Androgen Therapy - BAT) seemed to be effective in some small (29 patients) trials in men who were still hormone sensitive and had undetectable or minimal metastases. They alternated 3 months of each. Here's what they learned so far:



As might be expected from some of my posts, I would opt for testosterone replacement therapt [TRT].

You should expect PSA to rise as T is restored, so don't be concerned by the first reading. You need to relax & wait for the trend. Hopefully, you will have a longiss PSA doubling time [PSADT], e.g. >18 months, or much longer.

Here is Dr Myers on the subject of TRT & PCa:



in reply to pjoshea13


An undetectable PSA is a good sign. I don't see any rush to anything more until our PSA starts to rise.

You are in a very good place. I am a fan of BAT but I think it is way overkill in your case with PSA undetectable and still sensitive to casodex and lupron. If your docs recommend T for QOL, go for it! I think testosterone replacement therapy and if so, aim to get a fairly high T level but within the normal range. (not supra T at this stage) PCa loves low-normal T. If PSA starts rising too fast lupron and/or casodex should knock it back, then stop them, see what it does. There is a good chance you will be able to cycle PSA from very low to low and back and get maximum bang from lupron and casodex.

in reply to kaptank


in reply to kaptank


Yiasou Theo...

Good luck, Good Health and Good Humor.

j-o-h-n Monday 04/01/2019 5:22 PM DST

See a Post I will Post.


Just curious, did you ever do gene mapping? Also was wondering what your overall opinion of the Proton therapy was, side effects?

in reply to sammamish

No gene mapping...proton therapy had almost no side effects, was comfortable, low key, very easy. I had 'splatter' type versus 'pencil beam'...I recommend proton...if indicated.

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