Erleada and PSA raising to 1000's

[Samdres]

Hello

Hope everyone is safe in this awful times. My dad got 7 chemo (Paclitaxel with Carboplatin) so far and his PSA went from 50 to 1200 and with chemo went done till 300. Dr said that cant go lower because seems the PSA stabilize around 300, she is trying Erleada just 15 days ago the PSA went from 300 to 1000 again. We are very worry because seems very aggressive and would like to know other people experience with Erleada. Do you think that the cancer cells are dying and the PSA is a false reading ? Please if anyone has a similar results and recommend what treatments we can move forward for better results ?

thanks

Sam

[Hidden]

Did he stop chemotherapy when he went on Erleada? If he is on Docetaxel, he can change to Cabazitaxel. That might work better for him. I don't see how such a large rise in PSA could be dying cancer cells. What did his doctor say about that?

[Samdres in reply to Hidden]

Yes, he stopped chemotherapy. His chemo was Paclitaxel with Carboplatin. When he was in 300 and when to 600 Dr decided to go with Erleada and today he went to get infusion and blood work and just realize PSA is 1000+. His appointment with the Dr will be next Wednesday, that is why i want to be ready with questions or back up plans because seems Erleada is not working.

[Tall_Allen]

It could be - retest in 2 weeks. But considering the resistance to chemo docetaxel, it may be resistant to hormonal agents as well. Perhaps switch from docetaxel to cabazitaxel+carboplatin. Did they do an IHC analysis? Does his cancer express PSMA and the androgen receptor?

[Fairwind]

How long has he had PC ? His age ? What was his Gleason score ? Has he had Zytiga and or Xtandi ? When were his last bone scans and CAT scans ?

[Samdres in reply to Fairwind]

He got diagnostic October 2019, he is 56. We haven't done Gleason score but in the Biopsy says : TP53 and PHLPP1 . No, he didnt try Xytiga. He tried Xtandi but got him really sick, causing a lot of burning in the stomach and cant tolerate after 2 days of usage. Bone scans were 15 days ago, right after Dr saw the increase of the tumors and decided to move with Erleada.

[Magnus1964 in reply to Samdres]

Zytiga and casodex are milder than xtandi and both are good choices.

[CalBear74]

I don’t understand the choice of paclitaxel and carboplatin. I would understand it if it were squamous cell carcinoma in the lungs but it makes little sense to me as a treatment for prostate cancer. Why not Jevtana? Has Lupron or Firmagon been considered? You have many choices, chemo and ADT, to choose to drive down his PSA. I think the PSA reading is accurate, But what do I know? Are you receiving this treatment from a US doctor?

[scarlino in reply to CalBear74]

It is possible the doctor believes his cancer has taken on qualities of small cell carcinoma hence the use of Carboplatin. They should ask their doctor about that. I didn’t see if the cancer is in bones or soft tissue or lymph nodes.

[Samdres in reply to CalBear74]

Yes, my dad lives in Maryland. He has met in the bladder and multiple in the liver and very small ones in the ribs ( when he got the diagnostics) now seems keep growing. Yes he started with lurpon but did not.do anything.

[CalBear74 in reply to Samdres]

Please read my past posts on IP6. Much of the research on this over the counter medication has been conducted by a university of Maryland medical professor Dr. AKM Shamsuddin. His book can be found at Amazon: “IP6 and Inositol”. I use enzymatic therapy’s IP6 powder from Allstarhealth.com.