After more than 4 months of no PSA test , I finally confronted the Covid-19 intimidation and got the test.It came back <0.003 again. It's almost one year of ADT(next month) after my oligometatasis CK radiotherapy. I don't know which of them is working.... may be both!
My question is ...is it time to have a break from ADT. Did my spot radiation ever worked?I had intermittent ADT for several times in the last 8 years but never had it on for more than one year and never allowed PSA over 1 ng. l need your opinion,my friends.
Beautiful morning here in Bucharest.Wish you the same wherever you are.
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Alinur
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I lived in Bucharest for several months. Beautiful city! (except for the Soviet monstrosities). It depends on what your goal is. If you want to give yourself a holiday, you can come off the ADT for a while. If you want to suppress the cancer for as long as possible, you would stay on it, perhaps adding a stronger hormone therapy, like Zytiga.
Thanks TA.I was waiting yr reply. Welcome back to Bucharest anytime.It changed alot. Be my guest. I don't think they will accept that combination here(ADT+Zytiga) while ADT is working!
Is the scale used to report PSA < 0.003 different from the scale used when PSA is reported like 0.05? When I used Quest they reported PSA < 0.1, PSA = 3.4. At NIH I had PSA reported like 2.38. The same is done at Penn Medicine reporting PSA using 4.48, 0.17, etc. When is PSA test called ultra-sensitive?
I have never favored "breaks" from ADT drugs. If a drug is working why stop. If you stop you give the cancer a chance to find a work-around and the drug then becomes ineffective.
Yes, all ADT drugs eventually fail. New lines of cancer cells grow and become resistant. Taking a break from the drug would or could give a new line the chance to break out.
but that hasn't been born out in any study, right? Many say that on this site but it's just a hypothesis still, correct? My MO says that intermittant ADT people live shorter because they break too long and let it get out of control. I think the difference also has to do with the 6-12 months lost when a person is off ADT, when the psa is higher, when the ADT stops working, so it takes longer for the PSA to do damage going from .1 instead of starting at a higher level (6-12 months of growth. Anyway, I'm not saying you're wrong, I'm just trying to hear different perspectives for learning.
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