I am new on this site . My fiancé was feeling un-well and had quite extensive blood tests. Everything was ok or within normal parameters, however his Derived Fibrinogen level was 5.75 g/L (2.0 - 5.3) Above high reference limit. His serum prostate specific antigen level was 0.31 ug/L (0.0 - 3.0), which appears normal.
I know nothing about Fibrinogen in fact I have never heard of it. Could somebody offer me a bit of guidance here please?
Cancer is a hypercoagulable state..it is a well known fact. Hypercoagulable state means that the blood has higher tendency of forming blood clots...sometimes with bad consequences such as thombosis, embolism resulting in strokes or heart attacks.
Fibrinogen is a blood protein which converts into fibrin to form a blood clot.
To keep blood less coagulable, foods such as ginger, garlic, turmeric ,onions etc might help.
In more severe hypercoagulable state ,your doctors might prescribe blood thinning meds and check blood tests called PT/INR to measure how thin the blood is.
Thank you for your very helpful reply LearnAll however I am sorry if I sound dim, but this is a new one for me. In your opinion would you say that John's result is particularly high, and should it be checked with another blood test in a few months time?
I dont think John's results are particularly high. This type of reading on derived fibrinogen can be seen in many cancer sufferers.
Make some changes in diet with addition of anti inflammatory foods and recheck the blood test in 2 months and its likely that it will fall back into normal range.
Did the doctor recommend meds like low dose (81mg) aspirin or coumadin ? What is john's PT/INR (prothrombin time/international ratio_)..if that is within normal limits, much less need to worry. What is his platelet count ?
No the doctor didn't recommend anything at all, no comments or discussion. I got the results on line, so I guess this is the norm for things s they are at the moment.
Blood tests are:
Clotting screen test
Prothrombin time - reference 11.4s (10.3 - 13.3)
International normalised ratio 1.0 INR (0.8 - 1.2)
Partial thromboplastin time activated 31.5s (25.7 - 35.3)
Activated partial thromboplastin time ratio 1.03 1/1 (0.8 - 1.2)
Platelet count - observation 252 10*9/L (150 - 400.0)
I have taken on road you have said regarding anti-inflammatory diet also garlic turmeric onions and ginger. Thank you for your advice.
These blood test results are very good. Why you are worried? There is no need to worry. His blood tests are showing that his clotting risk is equal to an average, healthy man. The foods mentioned can bring the results in even better range ....besides lowering PSA also to some degree.
John isn't feeling too good, although I think it is to do with his thyroid and low B12. I was only worried because I didn't know anything and the mention of "Above high reference limit", when scouting around for information was concerned about blood clots. As they say "a little knowledge is a bad thing". Thank you for reassuring me.
We do eat very well, and include the items you mentioned however, I shall be upping them now, and paying attention more on antinflammatory foods.
thank you again for taking the trouble to answer. (This site is fantastic)
Raising B12 level is easy. They have B12 sublingual liquid at pharmacies . A few drops of B12 liquid below tongue for 14 days can fully restore B12 level.
Thank you, we are on to it.
Be wary of supplements for B12, my MO Dr. Sartor, who is a well known PCa specialist advises against it. He says PCa loves B12.
Ed
Yes it is Margo. So so much wealth of information and everbody's support is from there own life experience good bad or not so good. I was re-Dx'd with advanced prostate cancer Aug 2019. Yeh, I had extensive radiation treatment zaps in 2005, ADT hormone med's 2008-2013. And throw in cardiac complicated multiple issues.
This site healthunlocked rocks!
You are still here depotdoug after an incredible journey which is all that matters. Thank you for you reply.
And just had a successful RF cath cardiac ablation procedure 9 days ago in my fav heart hospital here in SW Ft. Wayne. 5 hours of asleep doug while my EP doctor and about 10 support EP lab staff RF ablated my non-nicely conducting electrical signals inside my left Atria and PVeins in and out of atria.
NSR is a wonderful feeling to be in AFIB is not. Let's keep it that way. Nine years and 3 days ago I drove myself to that same hospital ER and cardiac arrested. 12 days in the CICU plus rehab. I'm now on my 2nd ICD/Pacemaker device implanted last Jan.
Now battling advanced PCancer since Aug 2019. Too much information Not really.
Still fighting.
Doug
Fibrinogen is a marker of inflamation & I feel strongly that subclinical inflamation should be addressed, even if only mildly elevated. See:
healthunlocked.com/advanced....
healthunlocked.com/advanced...
-Patrick
Such a lot to read for a new subject like this, really don't know what to think. As I posted above the rest of John's bloods seemed to be ok. What would you do if this was your blood result Patrick?
Hi Margo,
I would get hold of a reliable brand of Nattokinase & perhaps have him take 2 of the caps daily. It can bring fibrinogen down, but it will also dissolve microclots if someexcess fibrinogen has converted to fibrin - [a D-dimer test can verify that this is not the case.]
amazon.com/Doctors-Best-Nat...
I would also take some polyphenols (lots to choose from) to address inflammation.
I like curcumin:
swansonvitamins.com/now-foo...
Best, -Patrick
Just looking at the Nattakinase, it says all vitamin K removed. John is taking Bit D/K2 is that ok do you think?
Nattokinase comes from a Japanese fermented product - natto - which contains nattokinase & vitamin K. To sell nattokinase as a standalone product that people on Warfarin could use, the K is removed.
He should continue with the K2 IMO. It helps get calcium back into bone & out of arterial walls.
-Patrick
Would you please provide more information about your fiance's advanced prostate cancer? Does he have extensive metastases? What is he taking to keep his PSA low? ADT? Estrogen patches?
Good morning Tall_Allen , my fiance does not have or at least I don't beleive he has prostate cancer. I was concerned about the blood result posted above, nothing else.
So why are you posting on a site for men with advanced prostate cancer?
Because I was searching for information on Fibrinogen, and this site came up, and I posted my question as you can see clearly above. Sorry if it bothers you mate, but I have had some very helpful replies.
It doesn't bother "mate" he was just trying to figure out why you're in this group?...People here are fighting prostate cancer....
BTW you never mentioned what is bothering your fiance? i.e. Not feeling well.... (we here assumed it was his prostate since you were here)...Got it now?
Good Luck, Good Health and Good Humor.
j-o-h-n Saturday 05/16/2020 3:57 PM DST
John my fiancé had a blood test which showed the above, and the more I delved, I could see it was serious, I had never heard of it before. Whilst on Google I happened upon this site. I didn't think any one would mind helping out a Damsel in Distress. I feel as if I have stepped into a private Masons Circle with rolled up trouser legs. I appreciate this is a serious site, and from the other HU's I have been helped enormously for my own health issues, and people have gladly helped with out question. I have the information I need thanks to a couple of chaps on here. So I will bid farewell. Thank you
"Sorry if it bothers you mate, but I have had some very helpful replies."
It doesn't bother "mate" he was just trying to figure out why you're in this group?...People here are fighting prostate cancer....
BTW you never mentioned what is bothering your fiance? i.e. Not feeling well.... (we here assumed it was his prostate since you were here)...Got it now?
Attitude my dear.... Attitude....
Masons Circle with rolled up trouser legs? NO NO sweetheart Damsel.... Just a bunch of us fighting for our lives........Put that in your spot of tea and drink it..........
Farewell and -
Good Luck, Good Health and Good Humor.
j-o-h-n Sunday 05/17/2020 2:57 PM DST
FYI matey
Fibrinogen
Description Fibrinogen is a glycoprotein complex, made in the liver, that circulates in the blood of all vertebrates. During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin and then to a fibrin-based blood clot. Fibrin clots function primarily to occlude blood vessels to stop bleeding. Doctor Wikipedia
Good Luck, Good Health and Good Humor.
j-o-h-n Saturday 05/16/2020 4:01 PM DST
Not really. Just a recommendation.
AST and ALT levels higher a week after stopping Zytiga? 
He lived a wonderful life
Lucrin after orchidectomy
Statin Drugs and Prostate Cancer recurrence
After Radiation Issues
