Should I still have my Zoladex injection

[Chubby42]

Hi folks

I have been on Zoladex for 2& 1/2 years & my PSA has gone from 0.01 to 0.2 It could be 3 - 4weeks before my next Onc appointment, I know you generally need at least 2 PSA tests before you get a clear picture on ones PC but my next Zoladex injection is due next week do I still just go a head with it will it have any effect on my next treatment still having a 3 month injection or is it better to ask for a monthly injection instead.

Cheers

[Magnus1964]

I would have the injection. If your PSA rises again maybe it's time to add another ADT drug like casodex or abiraterone.

[Chubby42 in reply to Magnus1964]

Ok thanks I guess it would be ok to have 2 different ones in your system.

[Magnus1964 in reply to Chubby42]

It's done quite frequently.

[RyderLake2]

Hello,

I would stay on the Zoladex. It is an agonist. The only monthly shot that I know about is Firmagon. It is an antagonist. Different mechanism of action. I have been on both and prefer Zoladex. It serves as a good base down the road when you may need to add Abiraterone or Enzalutamide. Good luck!

[Chubby42 in reply to RyderLake2]

Yep think I'll leave it at the 3 monthly injection.

Thanks

[Tall_Allen]

Better to get a 6-month injection these days.

[Chubby42 in reply to Tall_Allen]

I think in the UK its only 1 or 3 months.

Cheers

[Ausi]

I’m still on Zoladex after about 7 years, I’ve had other treatment while on it, Enzalutamide and Radiation a few times for mets to lymph node and spots on my hip (PSA 30 then dropping to 5). My MO said that Zoladex stops the body producing testosterone.

[Chubby42 in reply to Ausi]

Hi Ausi Wow 7yrs is great, has your PSA gone up while you have been on Zoladex.

Cheers

[Ausi in reply to Chubby42]

I’m not sure how well it’s working, yes, like you my PSA after initially coming down, kept going up but probably slower than if I was not on it. As mentioned the MO said it stops the body producing testosterone, other ADTs stop the tumore and pathways (I think). I’ve had to have other recent treatment, as mentioned. I’m presently PSA 3.9 which was after radiation of a couple of spots in Dec. PSA then was 16. I’ve had 3 series of radiation treatment last year, about 30 days each series.

I’m surprised you’re not getting more responses as there are some pretty smart blokes that know more. I think TA (Tall Allen) has posted more about Zoladex previously. Good luck.

[Chubby42 in reply to Ausi]

Hi Ausi thanks for the reply I'll keep up with my 3 monthly Zoladex my next Onc appointment is on June so not too far away.

I'm from Perth but live in the UK where abouts in Oz are from.

Cheers m8

[Ausi]

The Gold Coast, we’re just getting over Covid, like WA no new cases in Qld.

Keep safe.

[Chubby42 in reply to Ausi]

Ok cool most of my family in WA

Take care too m8