Alk Phos Flare?

[Shanti1]

Similar to how PSA can go up before it goes down as dying cancer cells release PSA in response to treatment, can the same phenomenon happen with Alk Phos in response to radiation to bone lesions? Thank you everyone.

[Shanti1]

Thanks Nal!

[LearnAll]

YES. Absolutely ! My initial ALP at time of diagnosis was 191...after one week being on Casodex , ALP skyrocketed to 490...after that ALP fell like a rock and kept going down for next 8 months ...ending up at 59. Now it hovers between 60 and 70.

[Shanti1]

Wow LearnAll, that is a big swing in the ALP. Thank you for sharing your experience and numbers, very helpful.

[Tall_Allen]

Yes- for BONE alkaline phosphatase. No- for liver alkaline phosphatase.

[Shanti1 in reply to Tall_Allen]

Thank you, good distinction.

[immunity1]

Yes. Clearly if you are reading total Alk Phos levels you need to be monitoring your lever function tests, if not liver Alk Phos.