Loratidine

[Graham49]

This cheap over the counter antihistamine that is supposed to be none sleepy has two side effects useful to me (they may not apply to others). It is slightly sedative and it reduces urination slightly. I have started taking 10mg before bedtime. It also has anti cancer properties, see paper below.

Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment

Author links open overlay panelAnne-MarieEllegaardaChristianDehlendorffbAnna C.VindcAtulAnandaLuiseCederkvistbNikolaj H.T.Petersena1JesperNylandstedaJanStenvangcAndersMellemgaarddKellØsterlindeSørenFriisbMarjaJäätteläa

doi.org/10.1016/j.ebiom.201... rights and content

Highlights

Use of cationic amphiphilic antihistamines is associated with reduced mortality among patients with non-localized cancer.

Clinically relevant concentrations of cationic amphiphilic antihistamines sensitize cancer cells to chemotherapy.

Clinically relevant concentrations of cationic amphiphilic antihistamines revert multidrug resistance.

Research Context Cationic amphiphilic drugs (CADs) induce lysosomal membrane permeabilization and cell death preferentially in cancer cells. Here, we show that antihistamines with CAD structure, i.e. astemizole, ebastine and loratadine, sensitize cancer cells to chemotherapy and revert multidrug resistance even at low, clinically relevant concentrations. The significance of these experimental findings is supported by an association between CAD antihistamine use and reduced mortality among patients diagnosed with non-localized cancer, especially among those receiving concurrent chemotherapy. These findings are immediately translatable to clinical trials, as loratadine and ebastine, are safe, inexpensive and approved for clinical use.

Abstract

Non-small cell lung cancer (NSCLC) is one of the deadliest cancers worldwide. In search for new NSCLC treatment options, we screened a cationic amphiphilic drug (CAD) library for cytotoxicity against NSCLC cells and identified several CAD antihistamines as inducers of lysosomal cell death. We then performed a cohort study on the effect of CAD antihistamine use on mortality of patients diagnosed with non-localized cancer in Denmark between 1995 and 2011. The use of the most commonly prescribed CAD antihistamine, loratadine, was associated with significantly reduced all-cause mortality among patients with non-localized NSCLC or any non-localized cancer when compared with use of non-CAD antihistamines and adjusted for potential confounders. Of the less frequently described CAD antihistamines, astemizole showed a similar significant association with reduced mortality as loratadine among patients with any non-localized cancer, and ebastine use showed a similar tendency. The association between CAD antihistamine use and reduced mortality was stronger among patients with records of concurrent chemotherapy than among those without such records. In line with this, sub-micromolar concentrations of loratadine, astemizole and ebastine sensitized NSCLC cells to chemotherapy and reverted multidrug resistance in NSCLC, breast and prostate cancer cells. Thus, CAD antihistamines may improve the efficacy of cancer chemotherapy.

[LearnAll]

Graham49,

You are right. I have read research about CIMETIDINE having anti cancer properties.

Interestingly, one of the side effect of Cimetidine is just like Lupron..some increase in size of male breasts if used for long time.

[Graham49 in reply to LearnAll]

The side effects look a bit nastier for Cimetidine. I have taken Ranitidine which is a newer more powerful version, for heartburn. However since I have gone mostly plant based eating, I rarely get heartburn.

[Manilo in reply to Graham49]

Oral ranitidine is not on sale anymor due to cancer issues

[tango65 in reply to LearnAll]

It is not ADT, cimetidine increases production of prolactin. Prolactin could make the cancer worst.

ncbi.nlm.nih.gov/m/pubmed/3...

[Ralph1966 in reply to tango65]

WOW. This article dated 1978?

Bohnet HG, et al. Acta Endocrinol (Copenh). 1978

[cesces]

Claritin

[cesces in reply to cesces]

"Ranitidine" is Zantac used for gerd

[cesces in reply to cesces]

"Cimetidine" is tagamet also used for gerd

[Graham49 in reply to cesces]

Yes, I first took this for allergy to dust mites.

[cesces]

"non-localized" means metastasized

[Graham49 in reply to cesces]

That is not my understanding of "non-localised". I was diagnosed with non-localised because it had broken through the capsule but no new cancer colonies were detected. If they had been detected it would have been diagnosed as metastised.

[cesces in reply to Graham49]

You are probably right.

[kapakahi]

started taking loratidine 4 months ago when I read that article - since I have allergies anyway, switched from cetirizine - followed links I found here: canceractive.com/article/ca...

there's also this: ncbi.nlm.nih.gov/pmc/articl...

added cimetidine a couple of months ago to go with mebendazole

[JLS1 in reply to kapakahi]

Thank you!!! This is also very interesting:

Building an off-label drugs protocol for cancer?

26 October 2019

canceractive.com/article/an...

[Graham49 in reply to JLS1]

Thanks for the link. I'm not to sure about the beta blocker as a blood pressure medication though. Some observational studies have shown beta blockers to be associated with reduced survival, see paper below. ARBs (ATR blockers) Are associated with increased survival for post prostatectomy patients, which I am one. I have changed from a Calcium Channel Blocker (Amlodopine) to an ARB (Valsartan).

prostate cancer survival after radical prostatectomy in Finland—A nationwide cohort study

Eerik EE Santala Antti Rannikko Teemu J Murtola

First published: 15 August 2018

doi.org/10.1002/ijc.31802

Citations: 7

Conflict of interests: Teemu J Murtola: Consultant fees from Astellas and Jansen, Lecture fees from Astellas, Jansen and MSD. Other authors do not have any conflict of interests.

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Abstract

Antihypertensive (anti‐HT) drugs targeting renin‐angiotensin‐aldosterone (RAA)‐ system have been associated with improved prostate cancer (PCa)‐specific survival. Challenge is that often multiple drugs are used simultaneously. We evaluated the association between use of anti‐HT drugs and PCa survival among 14,422 surgically treated Finnish PCa patients. Information on drug purchases was obtained from a national prescription database. We used Cox regression to calculate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for risk of PCa death and initiation of androgen deprivation therapy (ADT) with adjustment for age, tumor extent, use of statins and for Charlson Comorbidity Index. Angiotensin‐converting enzyme (ACE)‐ inhibitors, angiotensin‐ receptor (ATR)‐blockers, diuretics, calcium‐channel blockers, beta‐blockers and other anti‐HT drugs were analyzed as separate time‐dependent variables to model simultaneous use. Overall anti‐HT drugs were associated with an increased risk of PCa death. Conversely use of ATR‐blockers was associated with decreased risk of PCa death (HR: 0.43, 95% CI: 0.26–0.72 and HR: 0.60, 95% CI 0.37–0.97 for pre‐ and post‐diagnostic use). Similar risk decrease was not observed in other drug groups. Anti‐HT drugs were also associated with an increased risk of starting ADT, with the exception of ATR‐blockers (HR: 0.81 CI:0.71–0.92). ATR‐ blockers differ from other anti‐HT drugs as the survival is better in users of this drug group. The result partly supports the role of RAA system in PCa progression. Nevertheless, the risk decrease was not observed in ACE‐inhibitor users. Further research is needed to elucidate the molecular mechanism for the potential anticancer effect of ATR‐ blockers.