A new strategy to prevent chemoresistance with PROTACs

[Maxone73]

UArizona Cancer Center member Noel Warfel, PhD, co-led a research team that created and patented technology to combat anti-cancer drug resistance

cancercenter.arizona.edu/ne...

[KocoPr]

Here is the full article they referenced

cell.com/cell-chemical-biol...

[KocoPr]

Very promising now can we fast yrack this PLEASE!

[Maxone73 in reply to KocoPr]

Get ready to move to China soon!

[gsun]

It says the PIM kinase has a role in proliferating cancer cells. What is the role of it in normal cells? What might be the side effects of degrading it?

[Maxone73 in reply to gsun]

Normally they target what has not effect on normal cells or at least not much effect. PIM kinase is already a target from what I understood, it's "just" that this kind of degrader is more powerful and irreversible (from what I understand...and the irreversible part is maybe what makes me sweat).

Let's say that to our actual knowledge they are not too important for normal cells: "When it is over expressed it may lead to cancer development by three major ways; by inhibiting apoptosis, by promoting cell proliferation and also through promoting genomic instability. Expression in normal tissues is nearly undetectable. Recent improvements in the development of novel inhibitors of PIMs have been reviewed. Significant progress in the design of PIMs inhibitors, in which it displays selectivity versus other kinases, has been achieved within the last years. "

ncbi.nlm.nih.gov/pmc/articl...

irreversibility should worry us to a certain extent, we know from our good friend PCa that cells (even normal ones) can use different pathways to do the same "action"

[j-o-h-n]

Good friend eh? Mine are first cousins.......

Good Luck, Good Health and Good Humor.

j-o-h-n

[Maxone73 in reply to j-o-h-n]

I am Italian, half of the population here is "my cousin"

[j-o-h-n in reply to Maxone73]

Yep, and every fifth one is called "Old Uncle Carmine" the guy with the pull my pinky trick...........

Good Luck, Good Health and Good Humor.

j-o-h-n