Have question about drug Talazoparib.

[Parscore]

Does anyone have any personal experience with taking Talazoparib alone? Or info or involvement in trial using Enzalutamide and Talazoparib?

[Tall_Allen]

It's only approved for breast cancer, so men with prostate cancer can only get it "off label" (very expensive) or in a clinical trial by itself (below) or randomized (to placebo or talazoparib) with enzalutamide (below).

clinicaltrials.gov/ct2/show...

clinicaltrials.gov/ct2/show...

If you want to talk to a man who has used it, you can ask the investigator of the Phase 2 trial if anyone has given consent to be contacted. It's a small trial, so it is unlikely,. On the larger randomized trial, no one knows for sure who has taken the drug.

[Parscore in reply to Tall_Allen]

Thank you for the input

[tango65]

Does your cancer have DNA repair defects such as BRCA, ATM, CHECK2 etc?

This type of drugs are mainly effective in cancers having this type of defects.

I ask, because personally, I will not enter a clinical trial with this kind of drugs unless the cancer has DNA repair mutations, due to the undesirable side effects and I believe a low chance of benefits if these defects are not present.

These are some of the side effects of this drug:

rxlist.com/talzenna-drug.htm

[kidclutch]

my dad has an ATM defect and did a trial with avelumab + talazoparib. it did not work for the ATM mutated patients and caused a lot of bad side effects which cleared almost immediately after stopping talazoparib. that’s my only real knowledge of it.

[Maleko808]

I am on the Talapro2 trial which is enzalutamide and talazoparib/placebo. As Tall Allen said dont know if I am on talazoparib or not. It's been 6 weeks and the only SE I notice is fatigue and a small bit of neuropathy. My PSA dropped for 14.7 to 1.1. I will have scans next week to compare against baseline prior to starting trial.

[topofthemountain in reply to Maleko808]

I commenced the same trial this week. I took the second day of tablets yesterday. Except for a little of fatigue I have no other side effects. I am looking forward to excellent results like you.