"Dairy-heavy diet linked to prostate cancer risk." That is how the Times [UK] is responding to a new meta-analysis.
The study [1] is in The Journal of the American Osteopathic Association, which is new to me as a source of PCa studies (draw your own conclusions, but more on that below), & the title is actually "Effect of Plant- and Animal-Based Foods on Prostate Cancer Risk".
The authors are: John Shin, Denise Millstine, Barbara Ruddy, Mark Wallace, Heather Fields.
Other papers from Heather Fields & co:
2016: "How to Monitor and Advise Vegans to Ensure Adequate Nutrient Intake." Fields H, Ruddy B, Wallace MR, Shah A, Millstine D, Marks L.
The Journal of the American Osteopathic Association
2016: "Is Meat Killing Us?" Fields H, Millstine D, Agrwal N, Marks L.
The Journal of the American Osteopathic Association
2016: "Are Low-Carbohydrate Diets Safe and Effective?" Fields H, Ruddy B, Wallace MR, Shah A, Millstine D.
The Journal of the American Osteopathic Association
Looks like Heather is a house writer for the journal.
The full text of the new meta-analysis is below [1].
I'm not commenting on it, since I read somewhere (definitively) that "Cow juice is OK" LOL
PC3 cells treated with 1 mg/mL of α-casein and casein showed increased proliferation (228% and 166%, respectively), and the proliferation of LNCaP cells was also enhanced by 134% and 142%, respectively.
CONCLUSIONS:
The milk protein, casein, promotes the proliferation of prostate cancer cells such as PC3 and LNCaP.
It's complicated, but in essence Casein is absorbed as AA's and Tryptophan, processed by the liver to increase IGF-1, which in turn is believed to suppress PTEN as seen in this diagram....
Here's a synoptic model of amino acid - and exsomal miR-mediated signaling of milk for the activation of mTORC1-mediated postnatal growth. From it, you can clearly see that whey protein (WP)-derived leucine, isoleucine and valine stimulate insulin synthesis. WP (especially Trp) induces the incretrin GIP, which will further enhance insulin synthesis. Peptide fragments of WP hydrolysis competitively inhibit DPPIV, thereby extending GIP bioactivity. GIP via GIP-R on somatotroph pituitary cells stimulates the synthesis of GH, which up-regulates hepatic IGF-1-synthesis, further augmented by insulin and Trp. Leucine derived from milk proteins increases GLP-1. Increased insulin/IGF-1 signaling via inhibition of TSC2 activates mTORC1. WP-derived leucine via Rag/Ragulator interaction promotes the activation of mTORC1. mTORC1 stimulates lipid synthesis by phosphorylation of lipin1 and activation of S6K1, which enhance lipogenesis. Milk is hypothesized to operate as an exosome-driven miR transfection system of metabolism to increase mTORC1-driven anabolic reactions of the milk recipient. Especially, milk exosomes containing miR-21 may enhance mTORC1 signaling by suppression of tumor suppressor proteins PTEN, Sprouty and PDCD4.
As you grow older, the last thing you want is to continually suppress PTENS (which are tumor suppressor proteins) by consuming milk or milk products; especially if you are male and at risk for prostate cancer.
Wow, that is complicated, but it sounds like inhibition of PTEN also boosts protein synthesis, which is a good thing for the non-cancer cells I'd like to keep healthy. Also, it doesn't say how much it inhibits PTEN and for how long.
That said, I have reduced my intake of dairy, but not eliminated it completely. This does make me feel a bit better about drinking whey protein.
I have heard that using toilet paper causes rectal cancer,. In fact over 99% of people that have rectal cancer have used toilet paper. Definite proof!!!
So how are you doing after 12 years of this crap. I remember visits to grandma and grandpa at the farm. Sears catalogues and corn cobs. They never got rectal cancer. Or nasal cancer. Lived into their '90's. The good ole days of stepping in cow pies. Enjoy.
You are not only a connoisseur of humor, but also of vintage musical videos. Do you just drive your wife crazy, or do you have your own little padded room? All nine kids who were down on the farm left for the city lights. Toilet paper, electricity and running water. And a toilet! Boy, do we take things for granted.
Bovine Milk Lactoferrin Selectively Kills Highly Metastatic Prostate Cancer PC-3 and Osteosarcoma MG-63 Cells In VitroJoana P. Guedes,1,2 Cátia S. Pereira,1,2 Lígia R. Rodrigues,2 and Manuela Côrte-Real1,*
This study done last year would contradict the often thought of milk being bad. Some of these papers are difficult reading so if anyone can translate the technical jargon and concur that milk’s ok, I’d appreciate it.
Coffee time (with milk!)
Ian
My dad ate a heavy diet of whole fat dairy before getting sick.
You would think that the leading dairy states, California, Wisconsin, Idaho, would have some of the highest prostate cancer death rates but they're not in the top twenty. Everything we do is really killing us, that's why Kierkegaard called life the "sickness unto death"
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