Anyone having experience, or more info, regarding this:
"Acyline is a GnRH antagonist available in an oral dosage form, in contrast to current injectable therapies. The advantage of an oral agent would eliminate the inconvenience of injections, avoid injection site reactions, and allow individualized dosing regimens.44 In an initial study of healthy men, oral administration of acyline suppressed testosterone and gonadotropin levels without unwanted side effects, boding well for its potential utility in the management of prostate cancer."
I just did a search on Pubmed for (acyline prostate cancer). There were only seven hits. I skimmed the abstracts of all seven and found that not one of them was an actual report of a test of acyline with PCa patients. They were all reports of studies on very small numbers of healthy young men. All noted a reduction of testosterone levels though some noted no change in PSA and at least one, if I interpreted it correctly, found no change in the amount of testosterone inside biopsied prostate cells.
I also searched the FDA website and could not find any evidence of acyline being an approved drug for anything.
So it seems like this isn't going anywhere or, if it is, it's going v-e-r-y s-l-o-w-ly.
Alan
Discontinued for use in prostate cancer early on in investigation. Should you want to read the various clinical trials from roughly ten years ago, search acyline merrion
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