Olaparib

[Goldberg]

Starting my fourth week of Olaparib and will be seeing the oncologist at UCSF on September 20. PSA has gone from 52 to63In two months. The UCSF Oncologist is not recommending Radium 223. However my oncologist where I live is. Many Mets To my spine and lymph nodes. Any discussion about the differences of opinions. Thanks for all the help past present And future fellow warriors.

[Tall_Allen]

Why is the UCSF oncologist against it? Are your bone mets lytic?

[AlanLawrenson in reply to Tall_Allen]

What is 'lytic'?

[Tall_Allen in reply to AlanLawrenson]

Some bone mets eat away at bone tissue - "lytic." With most kinds of PC, the opposite happens - there is bone overgrowth causing them to become brittle and break - that's called "blastic."

[ctarleton]

I'm no doctor, but I might guess that you are getting the Olaparib because your genetics is a good match for trying this drug first. With the right genetic mutation, the response rate is relatively high, as cancers go, and they might first want to try to get the most out of it as they can, without confusing the situation with another concurrent treatment. See, e.g., this recent European news report.

ascopost.com/News/60138

As for the Xofigo (Radium 223), there are definite potential side effects, and various precautions and warnings, depending on individual circumstances. The overall response rate and any extra statistical Overall Survival time vs. the potential side effects might lead some doctors to hold off on it. See, e.g., some other European ideas on Radium - 223 suitability in some cases.

esmo.org/Oncology-News/EMA-...

You might also be interested in looking at some of the recent UCSF 2019 Patient Conference for Prostate Cancer videos to get some perspective of how several of the UCSF doctors have been thinking about other treatment strategies for advanced prostate cancer recently, as well as some "Prostate Cancer Genetics 101" information.

uctv.tv/2019-prostate-cance...

Fingers crossed for you. Good Luck!

Charles

[Goldberg in reply to ctarleton]

Thank you for your information I looked at both posts. I think I better understand why the oncologist at UCSF is holding off on RA 223. I am always looking for a better hammer to Wack a mole My cancer progression.