Zytiga and intermittent fever

[Sheryn11]

Hello everyone, my dad’s oncologist wants to start my dad on Zytiga. Our only concern is my dad had sepsis about a month ago, two surgeries and is not eating well. Now he’s also been having intermittent fever.

He was on chemo prior to the sepsis.

The oncologist said it’s ok to proceed with Zytiga.

Dad’s PCA history:

Gleason 7 (4+3) - diagnosed in 2017

TURP done in 2018

He was on hormonal therapy then it was stopped and radiation therapy was initiated.

Bone mets and some lung mets

Any advice or opinions you can share will be much appreciated! Thank you.

[tango65]

You need to consult with an internal medicine or infectious disease doctor to find out if it is OK to give prednisone to a patient who had a sepsis and is having intermittent fever.

[Magnus1964]

I don't know how old your father is but if he is advanced in age or in bad health chemotherapy could really knock him for a loop. ADT drugs can have bad side effects but not like chemotherapy. If you are concerned you might ask his doctor to start with casodex. It is the mildest of all ADT drugs.

[Sheryn11]

Thank you so much for your quick responses tango65 and magnus1964. He received Casodex in the past. He’s 84 years old and was in pretty good shape except for his bilateral knee osteoarthritis. He was only having nausea and vomiting during the first phase of chemo.

[Tall_Allen]

I don't see any reason why not. Zytiga+prednisone has no effect on the immune system, and there is no danger of infection from the pills.

[Sheryn11]

Thank you so much Tall_Allen.

I just spoke to his oncologist. He decided not to pursue Zytiga now until my dad's condition stabilizes. He's waiting on the culture test for the central line he recently removed. He's had the central line for almost two months.