Researchers characterize 3 ways in which the gene FOXA1 mutates to trigger prostate cancer

[Pierreb]

Hi All,

I stumbled upon this recently and thought I would post it as I know many of you guys doing your own research [I feel like some of you guys know more than the Dr's ] Hope this is helpful.!

sciencedaily.com/releases/2...

A new study from researchers at the University of Michigan Rogel Cancer Center finds that the gene FOXA1 overrides normal biology in three different ways to drive prostate cancer. They refer to the three classes as FAST, FURIOUS, and LOUD to reflect their unique features. The findings are published in Nature.

...

FOXA1 was previously known to be mutated in prostate cancer, but its biological functions were poorly understood. Scientists were uncertain if FOXA1 was an oncogene that fueled cancer or a tumor suppressor that hit the brakes. The Rogel Cancer Center team now clarified FOXA1's role as a driver oncogene, in addition to classifying the three novel FOXA1 alterations.

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"Oncogenes tend to be easier to develop therapies for as you could theoretically block them with targeted medicines," Chinnaiyan says. "However, FOXA1 is a challenging target because it is a transcription factor, a class of proteins notoriously difficult to inhibit with small molecules. However, scientists are now developing innovative strategies to go after these 'undruggable' targets."

[NPfisherman]

Saw this previously....the issue is how to add something to FOXA1 to render it inert or revert it back to it's prior state.... I do like science daily....Did you see the article on BD4?? Thanks for posting....

Fish

[Pierreb in reply to NPfisherman]

Good Morning Fish, I did not see the article on BD4 but I will google it. I found this on reddit.com/r/ProstateCancer/ It's not very active but occasionally someone posts something interesting. Hope you are having a good weekend.

[NPfisherman in reply to Pierreb]

OK....will post on it....in a few minutes....

Fish