Aspirin’s anti-metastatic effects.

[Broccoli24]

An interesting bit of news suggesting Aspirin may have anti-metastatic effects… though this research is specifically talking about lower grade cancers, and the article doesn’t mention Prostate Cancer.

The fact it’s being reported by BBC news feels like a heavier confirmation than the usual ebb and flow of research articles.

bbc.co.uk/news/articles/c1d...

[PCaWarrior]

Most of the existing trials are underpowered and/or did not report.

12. Estimated completion 2026: Add-Aspirin: A Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival After Primary Therapy in Common Non Metastatic Solid Tumours clinicaltrials.gov/study/NC...

[PSAed]

Thanks for posting that Broccoli24. I could do with a bit of luck . Last week my PSA results 0.35 were nearly double the previous 3 month result 0.19. I had a triple bypass Dec 2023 and have been on blood thinners ( amoungst other meds) since. I take 100mg of aspirin daily and will be on that for life.

" We'll see"...says the blind man!😀

[Broccoli24 in reply to PSAed]

Good luck to you! 🤞

[kainasar]

ASPREE, has shown increased death rates of users, also one must be aware of the rebound effect of discontinuing the long term use. Then, theirs gastro bleeding and thinning risk, and the interaction issues of NSAIDs. By the way, BBC is notorious for information counterfactual. If we dont have direct evidence of benefit fighting PC, should we gamble?

[Broccoli24 in reply to kainasar]

Thanks, good for thought.

[MarylandGuy in reply to kainasar]

Yup. My doctor took me off daily aspirin five years ago due to study.

[PCaWarrior]

This is a 2024 metastudy. I looked into this a few years back and started taking baby aspirin. Increases bleeding risk but also thins blood (important if you're doing pBAT). And also appears to potentially decrease cancer spread.

nature.com/articles/s41416-...

[Broccoli24 in reply to PCaWarrior]

Thanks very much… compelling reading!

Especially interesting is the possible overstated possibilities of gastro-intestinal bleeding caused by Aspirin.

[PCaWarrior in reply to Broccoli24]

Yeah. My PCP told me to take a baby aspirin a day for heart attack risk. My MO told me there might be some benefits for PCa (I don't think she can make a definitive statement without getting in trouble).

So I take a baby aspirin in the morning and one at night. 100% chance that I have PCa. Certainly greater than the chance I'll bleed...