Mixed results, but could have been worse

[Drcrunch]

I had mentioned that after three months on lymparza my psa went from 290 to 2000. I have no pain and feel good. I had a scan yesterday. Results indicate that any large metastases in the sacrum and right ilium have improved . Some new activity in ribs and sternum, but does not seem to justify a 2000 psa. My oncologist wants me to continue with lymparza and check psa next month. She says it is safe. Strange indeed.

[NPfisherman]

We have posted back and forth--the scan says better and the PSA says something else--not sure--ALP equivocal--don't know what to say...I guess listen to the MO--maybe check the PSA every 2 weeks--ask if that is possible--dead cells vs disease progression--this must be hell for you... I guess if the test in 2 weeks is a drop, you might feel like things are going right... for BRCA mutation--PARPs--but they don't work for everyone...what was your PSA at start and what was your PSADT? This might provide clues DrC.... Good luck...

Fish

[Drcrunch in reply to NPfisherman]

Psa at start of lynparza was 295. Doubling time was 60 days.

[Drcrunch in reply to Drcrunch]

Have never done chemo, but if psa does not drop, I have that. When I started nine years ago they did not do chemo upfront like now.

[NPfisherman in reply to Drcrunch]

Round to 300--in 4 months--1200....the plot thickens for sure...ask for a 2 week check and see IMHO... your call of course...hoping that number is much lower...

Fish

[NPfisherman]

If your PSADT is 6 weeks--I'd be worried--retest in 2 weeks seems like a plan...you were 256 at start and 4 months would be about 2000...worrisome--keep fighting DrC--

Fish

[Tall_Allen]

It's always a possibility that PSA will increase initially when you are taking cancer cell killing drugs like Lynparza.

[Drcrunch in reply to Tall_Allen]

Last 30 days the alk phos went from 340 to 360. Seems like slowing velocity.Was 90 four months ago.

[Hidden in reply to Drcrunch]

How do your blood counts look?

[Fairwind]

There is only one type of cell that makes PSA ...A big jump like that means SOMETHING is going on..You might check to see if NCT-03511664 (Vision) is being held anywhere near you...

[Drcrunch in reply to Fairwind]

Thanks, but chemo is a requisite. Never had chemo.

[Hidden]

A little history. May 4, 2004, DX’d with metastatic PCa and had my first injection of a Lupron. Two weeks later enrolled in a six month chemotherapy-hormone therapy trial. Two weeks later had a port installed. Then waited until after the 4th of July to commence so there there would be no early on interruption. July 5, 2004, I had my first infusion and thereafter every week for a six week cycle. Three cycles and ending 180 days later. I was most fortunate to receive early and aggressive systemic treatment. Continued with Lupron until February 10, 2010. Also had Casodex from January 8, 2005 until October 2, 2005.

I know zip about any of the new drugs like lynparza.....

GD

[Drcrunch]

Thanks for the review

[Hidden]

Dr . I’m shocked with your high Psa s ....we are all so different . Mine was never over 20 . I’m skating on clear ice for now . Except my MO just told me that there is some shadow on my lungs on my latest scans. Tha5 was never there before .He said it was probably an infection? What .. ? The mystery begins . Hopefully nothing . I’ll see next scan . MY Psa is in undetech ..my Nat Dr is concerned because I never had a high Psa ,that Psa might not be the best indicator for me . I hope not ..Time will tell. As Dorris day sang ............ “ Que Sara Sara “ ..........I’ve also yet to experience chemo . How are the polar bears doing? We have an amazing bloom in the Sonoran desert this year . Spectacular ! A botanist on tv said that she’s been seeing plants and flowers come up ,not seen in 15 yrs . Mama nature rules this earth . Take care DC.

[monte1111]

No advice from me. I am a know nothing. Just hope you find your way out of the maze. Seems like you have the old time chemo in your back pocket still. Worked for me, at least for now. Wishing you the best.