Bad news from four months on lymparza

[Drcrunch]

Since I am Brca 1 , it was felt that lymparza would be the perfect drug. But it was not to be. Over the four months of taking the drug, the psa went from 265 to 2000. The doctors were shocked, since I feel great and have no pain. The alkaline phosphatase went from 340 to 360 over the four months. I will get a scan and see what is going on .Never had chemo, so it may be in my future. Nine years since diagnosis this week.

[beatPC]

Good luck to you. A positive attitude can be the best healer. Stay strong.

[Tall_Allen]

They claim the new generation of parp inhibitors may be better. But these things are so individual.

[tango65]

You could discuss about getting a liquid biopsy to study cirulating cancer cells and/or cfDNA/RNA. With a high PSA and bone metastases they will be able to get enough material. Perhaps the cancer has other mutations that could be treated with specific drugs. The doctor will know what test to order.

There are clinicals trials to resensitize the cancer to enza or abi using niclosamide or indomethacin

clinicaltrials.gov/ct2/resu...

clinicaltrials.gov/ct2/resu...

Then you have the possibility of chemo, xofigo and the clinical trials for Lu 177 PSMA

clinicaltrials.gov/ct2/resu...

[Drcrunch]

Thanks . neuroendocrine with such a high psa does not fit in, but appreciate your input

[snoraste]

keep on fighting - and look for new medicine.

[Pierreb]

Sorry to hear. On to the next treatment! Stay positive and strong.

[j-o-h-n]

WTF WTF WTF

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 05/08/2019 11:15 AM DST

[monte1111]

I have no advice. Hope your scan can maybe narrow the problem. Good luck sir.

[Drcrunch]

I also produce alot of psa. On diagnosis, I was 3002 psa. Lupron brought it to. .o3 and went off all meds for one year and a half. So who knows.u

[NPfisherman]

I do wonder if the high PSA might be due to PCa cell death since you feel so well...Your ALP didn't move really...As you know, MD or former MD--the ALP is made up of bone and liver component. Did they isolate which one was involved?? Hoping things are better than you think... Keep fighting, brother.... 9 years...hope I am around in 9 years...

Fish

[Drcrunch in reply to NPfisherman]

My oncologist does not follow alkaline phosphate and thinks it means nothing.But others would argue that.

[NPfisherman in reply to Drcrunch]

That is why I question it....the ALP didn't move but the PSA did....that is why I wonder if this is PCa cell death vs disease progression.....especially if you have bone mets, then I would expect ALP to go north with PSA if disease progression...just my thoughts...I have been deleted 3 times today so what do I know in the minds of the powers that be...

Hoping the best for you, sir....

Fish

[Drcrunch in reply to NPfisherman]

Thanks for your input. I don’t know why they are deleting you. Maybe problem with website software. I feel great and no pain. That’s why oncologist doesn’t understand. Had scans today.

[NPfisherman in reply to Drcrunch]

Best of luck...hope the scans show much improvement...

Fish

[Hidden in reply to NPfisherman]

Your association with me brings deletion .

[Sherpa111 in reply to NPfisherman]

You better be!

[NPfisherman in reply to Sherpa111]

I better wish the best for him or I better be deleted or both??...LOL..

Fish

[Sherpa111 in reply to NPfisherman]

You better be around in 9 years!!

[NPfisherman in reply to Sherpa111]

After I had stereotactic radiation--ended December 26th, my wife and I went out in early January to a Chinese restaurant we like...We had been discussing my treatments...my fortune cookie that day was, "Believe in miracles !" Call me superstitious but I took it as a sign from above... as I say to my buddy, jdm3---

"Believe in a miracle----and hope" ... My wife says I promised her a lifetime and I better deliver...guess I have no choice...LOL... I'll do my best...Thanks....

Fish

[Hidden in reply to NPfisherman]

I once opened a fortune cookie and it contained no fortune. It was a couple years prior dx so it might have been an indicator . Confuses says : only those open to miracles ,can receive them .

[Hidden]

Dam Drcrunch , those are impressive Psa numbers ..what a wonder you feel great with no pain . Sorry the med didn’t work . Next! This really is a convoluted disease .. 😢

[Hidden]

Kick the shit out of it ... that’s all it deserves ...