Prognostic significance of elevated pretreatment systemic inflammatory markers ...

[pjoshea13]

New meta-analysis [1].

I had a series of posts on inflamation 2 years ago: [2] [3] [4] [5].

The basis problem of studies is that inflammation is used for prognosis - not as a signal for intervention.

A man may appear to be entirely healthy, but chronic sub-clinical inflammation is associated with poorer 5-year survival. Inflammation can be addressed.

Chronic inflammation is a signature of cancer. The culprit is the activation of NF-kB. NF-kB activation can be inhibited. Inflammation can be tamed.

In the new study:

"... pretreatment NLR {neutrophil-lymphocyte ratio}, PLR {platelet-lymphocyte ratio}, LMR {lymphocyte-monocyte ratio}, neutrophil, and monocyte counts may be effective predictive biomarkers for prognosis in patients with PCa."

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/309...

Cancer Cell Int. 2019 Mar 25;19:70. doi: 10.1186/s12935-019-0785-2. eCollection 2019.

Prognostic significance of elevated pretreatment systemic inflammatory markers for patients with prostate cancer: a meta-analysis.

Peng H1, Luo X2.

Author information

1

Department of Urological Surgery, Zhoukou Central Hospital of Henan Province, No. 26 Renmin East Road, Chuanhui District, Zhoukou, 466000 China.

2

2State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620 China.

Abstract

BACKGROUND:

Pretreatment inflammatory factors, including neutrophil, lymphocyte, platelet and monocyte counts as well as the ratios between them such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and lymphocyte-monocyte ratio (LMR) have been suggested as potential prognostic predictors for patients with prostate cancer (PCa). However, the prognostic effects remain controversial. Therefore, the goal of this study was evaluate the prognostic values of these markers for PCa patients using a meta-analysis.

METHODS:

Potentially relevant publications in PubMed and Cochrane Library were searched. Pooled hazard ratio (HR) with 95% confidence interval (CI) for overall survival (OS), cancer-specific survival (CSS), progression-free survival (PFS), recurrence free survival (RFS) and distant metastases-free survival (DMFS) were determined using a fixed or random effects model by STATA 13.0 software.

RESULTS:

Thirty-two studies involving 21,949 participants were included. Our pooled results demonstrated that a high pretreatment NLR (HR = 1.55, 95% CI 1.37-1.76), PLR (HR = 1.72; 95% CI 1.36-2.18), neutrophil (HR = 1.10; 95% CI 1.03-1.18 and monocyte counts (HR = 2.25; 95% CI 1.67-3.05) predicted inferior OS, while elevated pretreatment LMR (HR = 2.27; 95% CI 1.76-2.94) was correlated with favorable OS. Furthermore, the higher NLR (HR = 1.62; 95% CI 1.29-2.04) and monocyte counts (HR = 1.75; 95% CI 1.36-2.25), but lower LMR predicted worse PFS (HR = 2.18; 95% CI 1.58-3.02); poor RFS was only associated with NLR (HR = 1.12; 95% CI 1.04-1.20). The subgroup analysis showed that the higher NLR may be a predictive factor for OS only in patients with mCRPC and undergoing chemotherapy; while the higher PLR was only significantly associated with OS in localized PCa regardless of treatment.

CONCLUSION:

This meta-analysis reveals that pretreatment NLR, PLR, LMR, neutrophil, and monocyte counts may be effective predictive biomarkers for prognosis in patients with PCa.

KEYWORDS:

Inflammatory markers; Meta-analysis; Prognosis; Prostate cancer

PMID: 30962764 PMCID: PMC6434630 DOI: 10.1186/s12935-019-0785-2

[2] healthunlocked.com/advanced...

[3] healthunlocked.com/advanced...

[4] healthunlocked.com/advanced....

[5] healthunlocked.com/advanced...

[Hidden]

This is very interesting, I just posted something on this subject without seeing this post.

I think I had this when first diagnosed. I did also read that the prognosis is not as good. Thanks for the information.

[cujoe]

Thanks for posting, Patrick. Since I also have a blood cancer, I am always interested in anything that looks at blood components and cancer(s). Be Well - cujoe

[cujoe]

Surprising that there is so little comment on this post, since it is clear that inflammation is one of the key drivers of cancer in general and PCa in specific. Most importantly, as Patrick notes up front, it is something than can be controlled. I guess the community is over at the Youtube watching cat videos?? Oh Well - cujoe

[j-o-h-n in reply to cujoe]

pornos....

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 04/11/2019 5:22 PM DST

[cujoe in reply to j-o-h-n]

CAT pornos, no doubt. Meow, meooooowwww!

Be Well, cujoe-the-kitty-luvin-canine

[j-o-h-n in reply to cujoe]

pornos filmed in a cat house... Bow Wowwwwwwwwww

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 04/11/2019 6:31 PM DST

[cujoe in reply to j-o-h-n]

Woof, Woof, to you, too.

You are after all, A j-o-h-n, are you knot?

[monte1111 in reply to cujoe]

Good one. You want to see live action cat porno come on over to my house. Daily action. Had to get rid of the donkeys. The neighbors complained.

[cujoe in reply to monte1111]

Those donkeys are always making asses out of themselves. As for the neighbors, maybe you should have been charging them for the free entertainment. And the heck with CBD oil and wacky weed, I'm smoking catnip these days. But it tends to makes me want to rub up against the furniture, roll on the floor, and slap at dangling strings. Be Well - cujoe

[j-o-h-n]

Yep, it used to be my hobby.....I gave it up cause it ain't up.

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 04/11/2019 6:51 PM DST