Interesting human study with a total of 338 prostate cancer patients in Poland between 2009 and 2015: Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer Patients
“The study participants were categorized into quartiles (QI-QIV) based on the distributions of Se and Zn levels observed among surviving participants.”
“In the multivariable model, our findings show that individuals who were in both the lowest Se quartile and the lowest Zn quartile (SeQI-ZnQI) had almost a 21-fold lower chance of 5-year survival compared to patients in the highest Se and Zn quartiles (SeQIV-ZnQIV) (HR = 20.9; 95% CI = 2.80–156; p = 0.003).”
“The results we present (SeQI-ZnQI vs. SeQIV-ZnQIV; HR = 20.9; 95% CI = 2.80–156; p = 0.003) point towards a tremendous potential for improving patient outcomes.”
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I love it, but there are other research that point in the opposite direction especially for selenium…also in this paper they mention them at the end. I wish we had sone reliable info on the subject!
its interesting but this kind of study is a minefield. The ones who died the fastest had the most out of wack important biomarkers.
The cause of the difference could be the cancer state itself, or it could be the general health of the patient at the time - which in turn is more fertile grounds for cancer growth. In both scenarios,’taking supplements wont help delay the cancer progression.
the take away I guess is that to stand the best chance one should strive to be healthy so look at diet and exercise and biomarkers carefully.
Here’s some more studies on Selenium. My view is you want enough in your blood for normal health needs. If you have got cancer you may not have enough. But you don’t want too much.
From the NIH:
“Can selenium be harmful?
Yes, if you get too much. Brazil nuts, for example, contain very high amounts of selenium (68–91 mcg per nut) and can cause you to go over the upper limit if you eat too many. Getting too much selenium over time can cause the following:
Garlic breathNauseaDiarrheaSkin rashesIrritabilityMetallic taste in the mouthBrittle hair or nailsLoss of hair or nailsDiscolored teethNervous system problems
Extremely high intakes of selenium can cause severe problems, including difficulty breathing, tremors, kidney failure, heart attacks, and heart failure.
The daily upper limits for selenium include intakes from all sources—food, beverages, and supplements—and are listed below.
Ages Upper Limit
Teens 14–18 years 400 mcg
Adults 400 mcg”
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Whole Blood Selenium Levels and Selenium Supplementation in Patients Treated in a Family Doctor Practice in Golßen (State of Brandenburg, Germany): A Laboratory Study Inter Cancer Ther. 2018 Dec; 17(4): 1132–1136. Published online 2018 Oct 25. doi: 10.1177/1534735418807971
”Patients with cancer displayed significantly lower WBSL than patients without cancer, indicating a negative effect of tumors on Se uptake, absorption, or metabolism. Significant influences of age or sex were not observed. Selenite supplementation efficiently improved WBSL to concentrations considered necessary for health benefits.”
WBSL = whole blood Se level
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Association Between Blood Selenium Levels and Stroke: A Study Based on the NHANES (2011-2018) Published: 01 April 2023
”The negative relationship was stronger in participants with BMI 25–30 kg/m2 (OR = 0.23, 95% CI: 0.13–0.44, P < 0.001). Therefore, in American adults, the relationship between blood selenium levels and stroke was negative, with a linear tendency. In the future, a cohort study is warranted to further confirm this relationship.”
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Identification of Factors on Blood Selenium Levels in the US Adults: A Cross-Sectional Study Nutrients 2024, 16(11), 1734; doi.org/10.3390/nu16111734 received: 3 April 2024 / Revised: 13 May 2024 / Accepted: 30 May 2024 / Published: 1 June 2024
”A total of 6205 participants were finally included. The normal reference ranges of blood Se concentration were 142.3 (2.5th percentile) and 240.8 μg/L (97.5th percentile), respectively. The mean values of dietary Se intake, total Se intake and blood Se concentration of the participants were 111.5 μg/day, 122.7 μg/day and 188.7 μg/L, respectively, indicating they were in the normal range.”
“There was an inverse association between smoking and blood Se. Smokers, especially those smoking every day, had significantly lower Se intake than non-smokers, which was in agreement with previous findings in the USA [8]. Notably, drinkers with more Se intake showed lower blood Se concentration compared to non-drinkers with less Se intake, which was caused by changes in hepatic structure and function induced by alcohol [26]”
Association of Blood Selenium Levels with Diabetes and Heart Failure in American General Adults: a Cross‐sectional Study of NHANES 2011–2020 pre
”High blood selenium levels may be positively related to diabetes, while low blood selenium levels may be associated to heart failure. Appropriate blood selenium levels may help prevent diabetes and heart failure.”
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Zhao, K., Zhang, Y. & Sui, W. Association Between Whole Blood Selenium Levels and Triglyceride-to-High-Density Lipoprotein Cholesterol Ratio Among the General Population. Biol Trace Elem Res 202, 1998–2007 (2024). doi.org/10.1007/s12011-023-...
“Overall, WBSe levels were positively related to TG/HDL-C ratio, with a non-linear trend. Further research is required to determine these underlying mechanisms.”
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Doxycycline, small clinical trial
