Dexamethasone?

[ellyras]

My oncologist mentioned this drug-has anyone had experience of it and if so was it effective?

[GP24]

I would take it. Chris Parker, one of the best prostate cancer experts in the UK, writes:

„We use dexamethasone 0.5mg daily for treating CRPC. Men who respond well can stay on it for years. Toxicity relatively modest IMO“

twitter.com/PCaParker/statu...

Here is a study that reports a decrease of the PSA value in 47% of the patients treated with Dexamethasone:

eu-acme.org/europeanurology...

ncbi.nlm.nih.gov/pmc/articl...

Whether this translates to an extended overall survival is unknown. But patients prefer a lower PSA value.

[Hidden in reply to GP24]

Sound hopeful.. Thanks

[pjoshea13]

You became resistant to Enzalutamide but have not been offered Abitaterone+Dexamethasone - just the Dex?

Many men here will be familiar with the steroid drug, but not as monotherapy.

Here are some links that might be useful.

ncbi.nlm.nih.gov/pmc/articl...

ncbi.nlm.nih.gov/pubmed/254...

onlinelibrary.wiley.com/doi...

-Patrick

[Tall_Allen]

Given alone, it can slow down the cancer sometimes. But watch PSA closely, it usually does not last very long.

[Shooter1]

Helped me immensely during chemo. After first cycle was added to each infusion.

[tom67inMA in reply to Shooter1]

I also had it with chemo. Made me feel like superman for a few days. Great stuff!

[Rogersw]

When my psa went up to 19 in August 2016 a daily dose of 500micrograms was added to the lupron (prostrap) injection and my psa has fallen slowly to 6 so I assume it has been beneficial. I think it also reduced fatigue downside seems to be skin thining which means I cut and bruise easy.

[paulparry]

As indicated by others it is a steroid and usually used alongside another treatment. Given with chemo or radiotherapy in stronger doses but shorter periods.

If taken daily then should be a small dose. Helps with fatigue and increases appetite. Can cause muscle waste though.

[dadzone43]

An alternate corticosteroid like predisone and prednisolone.

[monte1111]

Used day before and day of chemo. Gave me bad insomnia for three days. Did not like it at all. Others here do not seem to report that issue.

[j-o-h-n in reply to monte1111]

I couldn't sleep just thinking about taking it......👀

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 03/30/2019 12:41 PM EDT

[tallguy2]

Used it with Taxotere chemotherapy. Never heard of it as a mono therapy until now. Thanks for posting.

[JimVanHorn]

Dexamethasone is also known as Decadron. It is a steroid like Prednisone. Both drugs are a form of Adrenalin and are used for many diseases to help healing.