Testosterone therapy may reduce PCa risk.

[pjoshea13]

A new study from Texas, UAE & Germany! German data.

"To investigate whether testosterone replacement therapy (TRT) reduces prostate cancer (PCa) risk via stabilizing serum testosterone (T) levels beyond simply elevating serum T levels and whether TRT reduces PCa risk due to low serum T levels at a young age."

"We derived an index, Maximum Decline of T Relative to Baseline (MDRB), to describe the magnitude of T declines and variations over time."

"We found the TRT group has more stable serum T levels (e.g. smaller drop-offs) during the follow-up period as compared to the non-TRT group, and the mean of MDRB is significantly higher in the untreated group (1.553 nmol/L VS 0.013 nmol/L ...). TRT significantly reduces the risk of PCa associated with T deficiency at a young age ..."

Seems like something is missing from that, although it's nice to see T deficiency being viewed as a PCa risk factor.

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/308...

Aging Male. 2019 Mar 12:1-7. doi: 10.1080/13685538.2019.1578739. [Epub ahead of print]

Testosterone therapy may reduce prostate cancer risk due to testosterone deficiency at a young age via stabilizing serum testosterone levels.

Zhang X1, Zhong Y2, Saad F3, Haider KS4, Haider A4, Clendenin AG1, Xu X1.

Author information

1

a Department of Epidemiology and Biostatistics School of Public Health , Texas A&M University , College Station , TX , USA.

2

b Department of Statistics , Texas A&M University , College Station , TX , USA.

3

c Global Medical Affairs Andrology, Bayer AG, Berlin, Germany and Research Department , Gulf Medical University , Ajman , UAE.

4

d Private Urology Practice , Bremerhaven , Germany.

Abstract

OBJECTIVES:

To investigate whether testosterone replacement therapy (TRT) reduces prostate cancer (PCa) risk via stabilizing serum testosterone (T) levels beyond simply elevating serum T levels and whether TRT reduces PCa risk due to low serum T levels at a young age.

METHODS:

We analyzed data of 776 hypogonadal men from a urology center in Bremerhaven, Germany through 2004-2016 to investigate whether the TRT group has more stable T levels and whether TRT can reduce the risk of PCa due to low serum T levels at an early age. We derived an index, Maximum Decline of T Relative to Baseline (MDRB), to describe the magnitude of T declines and variations over time.

RESULTS:

We found the TRT group has more stable serum T levels (e.g. smaller drop-offs) during the follow-up period as compared to the non-TRT group, and the mean of MDRB is significantly higher in the untreated group (1.553 nmol/L VS 0.013 nmol/L; p-value < .001). TRT significantly reduces the risk of PCa associated with T deficiency at a young age (p-value = .00087).

CONCLUSIONS:

TRT may reduce PCa risk via maintaining serum T levels within individual's normal range; T surveillance may be needed for males who have low serum T levels at a young age to monitor abnormal variations of T levels and ensure timely treatment when necessary to reduce PCa risk.

KEYWORDS:

Prostate cancer; long-term fluctuations of testosterone levels; testosterone deficiency; testosterone replacement therapy

PMID: 30857458 DOI: 10.1080/13685538.2019.1578739

[j-o-h-n]

Hi, This is to assure you that you haven't gone deaf and mute.

Good Luck, Good Luck and Good Health.

j-o-h-n Thursday 03/14/2019 8:50 PM DST

[George71]

pjoshea13,

How do you offset the effect of taking high doses of genestein which reduces testosterone level ? are you supplementing T ?

I am currently only taking Avadart every other day. PSA holding at 0.6 Not currently taking T replacement -- but considering doing so. My natural T level is between 480 to 550. I don't want to do anything that lowers T level. I think high T is therapeutic.

[pjoshea13 in reply to George71]

George,

I am using the BAT protocol.

With T at ~500, I don't know what kind of a drop you would experience, but it might be a concern.

-Patrick

[George71 in reply to pjoshea13]

pjoshea13,

Would taking trans-dermal T gel for a month and then discontinuing for a month be equivalent to what you are doing? If not please tell me what you are doing. I am 3 years post surgery 4 of 10 lymph nodes positive for PCa only taking Avadart every other day and many supplements.