Advice for Actinum Lu177 patient

[Sriyantra]

Hellow, I'm a 51 year-old, English male. Diagnosed stage four PCa in Aug 2017. No chemo, only Lupron and Enzalutamide (stopped the latter when quickly became castrate resistant).

I just had my required week 6 bloodtest result from the first cycle of this Nuclear medicine treatment in Heidelberg, Germany had in late January and my PSA has come down from 235 to 140 - a 40% response. I do not feel any better and my overall condition is very weak - mobility still very slow and restricted due to very extensive bone mets throughout psine, pelvis and shoulders.

Can anyone comment on this response to treatment compared to their experiences? I'm due to go back this coming Wed if the doctors tell me it's worth it. Alkaline Phosphatase still very high - 2400, red blood cell count in the 70s.

Also, although I'm only suffering so far with dry mouth upon waking in the morning I'm a bit concerned a second treatment may make this much worse. Can I use cold packs on my jaw area (will hospitral supply these?) and how how is it done, for how long etc?

Thank you!

Jason

[Tall_Allen]

Are you getting both Ac-225-PSMA-617 and Lu-177-PSMA-617? It can take several infusions to have a better effect.

Tell them about the dry mouth - there may be things they can do.

External icepacks have not been found to be very helpful:

ncbi.nlm.nih.gov/pmc/articl...

Botox may work better. They are also able to dilate them (sialendoscopy).

jnm.snmjournals.org/content...

[tango65]

I had Lu 177 PSMA treatment and I did not have any problem with the salivary glands. They asked me to apply cold packs over the salivary glands, before, during and about 10 hours after the infusion. Then they asked to chew lemon mints for a couple of days. It is different with the Ac 225 which it is known to significantly damage the salivary glands.