Google Doodle - caffeine - methyl donors.

[pjoshea13]

You may have noticed the chemical diagram in today's (Feb 8, 2019) Google doodle. It represents caffeine & is in recognition of the 225th birthday of its discoverer, Friedlieb Ferdinand Runge (8 February 1794 – 25 March 1867).

The thing I noticed is that the molecule has three - gasp - methyl groups (the CH3 bits of the diagram). Should we be worried?

Not at all - caffeine is not a methyl donor:

drbenlynch.com/methyl-group...

-Patrick

Caffeine is metabolized in the liver via a single demethylation, resulting in three primary metabolites, paraxanthine (84%), theobromine (12%), and theophylline (4%), depending on which methyl group is removed.

en.wikipedia.org/wiki/Caffe...

[jdm3]

Phew. Good to know. Love my coffee.

[j-o-h-n]

In the good old days it was a pleasure to share some coffee and couch with women. Now I share my coffee with my bib...

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 02/09/2019 1:44 AM EST

[cujoe in reply to j-o-h-n]

I think I used to date Bib??

[j-o-h-n in reply to cujoe]

If she was the type of woman who's arms were always around your neck, then that's Bib for sure. I'm dating her sister "Messy Bib" ....

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 02/09/2019 12:53 PM EST

[monte1111]

Careful. They say Balzac died from drinking too much coffee. 2 pots a day? I would be running around this place like a mad man. By the way, had Oceans 13 movie on in the background and one guy said, "Alligators walk faster than that." I instantly thought of you and gusgold. And then I realized, if a psychiatrist gave me a Rorschach blot test after being on this site for a year the result would be "Lock him up!"

[Haniff]

I have to have my cuppa every morning and in the late afternoon, just have to bro. I do have green teas in between as a guilty pacifier but nothing beats a flat white, coffee latte or a good old shot of the espresso...

Regards,

Haniff

[pjoshea13 in reply to Haniff]

The phytochemicals in the espresso would be more bioavailable. The casein protein in milk tends to bind to them.

-Patrick