The combination Seems to really help and I’m on both using Simivastin. Any clear indications if one statin is better than another? This quote in the article implied there was :
“The study also found that those who took one of three types of statin — atorvastatin, pravastatin or rosuvastatin — had longer survival than those who did not take any statins.”
The thoughts from this group are greatly appreciated as always.
Schwah
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Schwah
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I switched from rosuvastatin to atorvastatin which is lipophillic as opposed to hydrophilic. This was recommended by many here. As I recall, studies showed it took much higher doses of rosuvastatin than the lipophillic statins..
I currently use simivastin and it has worked well for me with no SE and I prefer not to change unless it will likely help my keep my PC at bay.. The article I referenced says: “atorvastatin, pravastatin or rosuvastatin — had longer survival than those who did not take any statins. A similar benefit was not seen with a fourth statin, lovastatin.” No mention either way of simivastin.
On the internet it says : “Atorvastatin, lovastatin, and simvastatin are lipophilic, whereas pravastatin, rosuvastatin, and fluvastatin are more hydrophilic”
So if you are right and the difference is that lipophilic statins should help more with PC, my simivastin should be fine. But the article I quote above also says, “A similar benefit was not seen with a fourth statin, lovastatin”.
So if lovastatin is in fact a lipophilic, and lipophilic is the type of statin that works best, why doesn’t lovastatin show any benefit? And more importantly for me (and perhaps others here), why should I believe that simivastin should help if another lipophilic statin (lovastatin) appears to be of no help?
Note that the chart is useful when managing LDL in general, but it does not address the variable degree of lipophilia (or lack of). My belief is that for men on ADT, it is important to target the PCa cells, rather than the liver, and that a lipophilic index should be added to dosage & equivalency. We need to stop the cells from being able to manufacture cholesterol - the first step in androgen production. (Note that Abiraterone also inhibits androgen production in tumors, but cholesterol accumulation in cancer cells (not just PCa) is an important issue too, IMO.)
Hi Pjoshea. Please take a look at my responses to Nal and 6357 above. I’m stumped. Looks like you’ve studied this a bit so hopefully you have some thoughts on the subject. Thank you
According to the table 5 mg of Rusovastatin has the same effect of 40 mg of Simvastatin?
Simvastatin (even 20 mg) caused severe muscles (neck/back/calves) pain for me, so I switched to Rusovastatin 5 mg which is the most powerful one among All statins, yet with the least side effects.
Dr Myers as far as I recall was taking Rusovastatin (Crestor) too!
My cholesterol was normal when I asked my doctor for Simvastatin. Doctors seem conditioned by BigPharma to believe that lower is always better. I don't agree with that, but I was happy that I did not need to beg for a prescription.
Ironically, it is men with low-normal cholesterol who probably need a statin most. Cancer cells accumulate cholesterol. When the supply is low, they will manufacture it.
I currently also use simivastin and it has worked well for me with no SE and I prefer not to change unless it will likely help my Keep my House PC at bay. Like you I read here that simivastin should do the trick. However, The article I referenced in my original post, says: “atorvastatin, pravastatin or rosuvastatin — had longer survival than those who did not take any statins. A similar benefit was not seen with a fourth statin, lovastatin.” No mention of simivastin.
On the internet it says : “Atorvastatin, lovastatin, and simvastatin are lipophilic, whereas pravastatin, rosuvastatin, and fluvastatin are more hydrophilic”
So if the difference is that lipophilic statins should help more with PC, the simivastin we both use should be fine. But the article I quote above also says, “A similar benefit was not seen with a fourth statin, lovastatin”.
So if lovastatin is in fact a lipophilic, and lipophilic is supposedly the type of statin that works best, why doesn’t lovastatin show any benefit? And more importantly for me (and probably you too), is why should we believe that simivastin should help if another lipophilic statin (lovastatin) appears to be of no help?
Thx Nal. That actually surprises me since you are so diligent with all your other supplements that have much less proof behind their efficacy than does statin use. Seems like if another statin was better and could be used at doses that do not impact your muscles, you’d be all over it. I’ll definitely reach out to Patrick and let you know if he has anything relevant on the use of one statin over another that could convince you to maybe make a change.
First so sorry for the pain you experienced from statins. I now understand why you are so reticent to make that one of your go to pills. And So sorry if I offended you. So you know, I never ever said your due diligence “was wasted on supplements”. In fact I think the opposite and read all your comments with great interest. What I said was o was surprised you were “so diligent with supplements that I thought had less proof than statins. “ That in no way meant it was wasted time. Only that I thought statins had more evidence of value than some of your other supplements. And after reading your response on the vast research you’ve done, perhaps even that statement was off base. Again so sorry if I offended. I have great respect for you and that was never my intention.
Shalom my friend....Newest study shows stress increases inflammation and I know how hard you work to minimize your inflammation. So chill brutha and don't take things personally. We are all very emotional on these subjects, probably cause it actually is "life or death".....
Thank you for posting this. My total cholesterol jumped from 202 to 235 in the last 3 months. My MO said that it is stress- related. I may yet start taking a drug to reduce cholesterol.
Wow I read your profile. You have a great team there. I love their aggressiveness. Why not add the statins? Seems like a no brainer.
Schwah
Mine is up also .. I pride myself on using little pharma, but adt and Rt has worked me over pretty good . A statin might save the heart a bit longer ... I’m pondering it myself . ✌️
True; I am still on Crestor for that reason. Without Dr Myers, I am having a very hard time getting my internist to change statins, if I wanted to. Dr drake unlike Dr Myers, doesn’t really want to prescribe what his NP would typically consider a non Pca drug
Dr. Myers preferred Crestor, I recall being on Simvastatin when I started seeing him and he recommended switching to Crestor. If I recall correctly he was concerned that certain other statins block a pathway used by Xtandi or other ADT drugs. I’ve been using Crestor in its generic form ever since, I’ve experienced no problems.
The fat soluble statins have different side benefits from water soluble, such as reducing neuro inflamation (MJF Foundation doing study for Parkinson's benefits). Long story short, I alternate days between Zocor and Lipitor. I've done this for years, always good liver and lipids bloodwork. I taylored my dosages to hit my cholesterol target range. This is NOT advice. Everything involves risks, do your due diligence. Peace.
Hello Nalakrats, there are indications that Vitamin D and metformin ameliorate the side effects of statins and reduce muscle pain. I used to have muscle pain with 10 mg rosuvastatin before taking VD and metformin. Now I tolerate 20 mg without muscle pain.
Cheers,
Phil
Mama! Good thing that you’re a professional chemist and all terminology comes easy to you . That a hard pronunciation for pain? Ouch ! 😣
I figured you were already taking the metformin and VD. There may be a genetic predisposition to experience muscle pain. Have you considered a DNA analysis? Cheers, Phil
: the destruction or degeneration of muscle tissue (as from traumatic injury, excessive exertion, or stroke) accompanied by the release of breakdown products into the bloodstream and sometimes leading to acute renal failure:
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