"Overall, the analysis revealed that the chances of surviving a cancer diagnosis were 20–30 percent greater among people who took aspirin compared with those who did not. This was true at any given point after receiving the diagnosis."
ingesting small amounts of ground up ... - Advanced Prostate...
ingesting small amounts of ground up willow tree bark daily improves cancer survival 20 to 30%
Written by
George71
To view profiles and participate in discussions please or .
Read more about...
25 Replies
•
did you see the post about Cholera vaccine
yah, I had a shot in the Navy in 1966 .. now days it is a dose you mix with water and drink. ITCandy had good input -- read the replies -- I have an appointment Tuesday with Dr. will get prescription for Dukoral.
From the paper -Patrick:
"Prostate cancer
Our searches identified 16 observational studies, listed in Table 1 and in our earlier report. [18] Fifteen focused on prostate cancer mortality and in ten the index of association suggested a reduction associated with aspirin, significant in three. In five studies the measure of association with aspirin exceeded 1.00, and in one the excess in prostate mortality with aspirin is significant.
A pooled HR based on the thirteen studies that report the association with aspirin using this index is 0.87 (95% CI 0.73, 1.05; heterogeneity p<0.0005 and Egger’s test P = 0.13). The omission of one out-lying study [53] gives HR 0.84 (95% CI 0.77, 0.92; heterogeneity p = 0.17; see S3 File).
Evidence on metastatic spread in prostate cancer associated with aspirin, comes from four studies. Pooling three of there, gives RR 0.52 (0.39–0.68), and another study [38] gives HR 0.23 (0.06, 0.91).
Five studies on prostate cancer also reported all-cause mortality and three show a reduction associated with aspirin, significant in two. However, in two other studies [41,55] the association with aspirin exceeded 1.00 and was significant in both. Four studies report the association with aspirin as hazard ratios and together these give HR 0.84 (95% CI 0.54, 1.30; heterogeneity P<0.0005 and Egger’s test for bias P = 0.42). The omission of one outlier [55] removes heterogeneity and gives for all cause mortality in the prostate studies, HR 0.73 (95% CI 0.66, 0.81; see S3 File).
The evidence on prostate cancer is therefore fairly consistent for both prostate cancer mortality, and the hazard ratio for all cause mortality also suggests benefit. Correspondence with the author of the one report that is seriously inconsistent [55] led to no clue as to why it differs markedly from the other studies. The reduction in metastatic spread associated with aspirin is otherwise marked and consistent. In one report [42], it is suggested that some inconsistencies in studies of this cancer may be introduced by a selective up-take of PSA (prostate specific antigen) screening, leading to bias resulting from an early diagnosis of cancer in subjects taking aspirin."
Patrick
Wouldn’t celecoxib which I’ve been on for many years have a similar benefit?
The PCa studies on NSAIDs make for dismal reading IMO. It's hard to get excited about any of them.
Where high doses are used chronically, the users are presumably dealing with high levels of pain & inflammation. Usage itself does not necessarily mean that inflammation is under control. e.g. it does not imply that C-Reactive Protein [CRP] has been brought close to zero. We don't have a study of high-dose usage in men who don't need them. LOL
But we do have data for low-dose aspirin used as a prophylactic.
In the case of aspirin, a low dose is all that is required to inhibit platelet aggregation. This means that it can inhibit clot formation. Which, in turn, means that it might inhibit metastasis.
So low-dose aspirin is different.
Here are the Celecoxib studies:
ncbi.nlm.nih.gov/pubmed/167...
ncbi.nlm.nih.gov/pubmed/197...
ncbi.nlm.nih.gov/pubmed/224...
ncbi.nlm.nih.gov/pubmed/283...
ncbi.nlm.nih.gov/pubmed/300...
-Patrick
Aspirin studies have had equivocal findings because of the way they've been done. Some say, yes (some with high dose, some with low dose); some say no - and there is a real risk of alimentary tract bleeding.
However, the recently published ASPREE randomized clinical trial found that cancer mortality was 31% HIGHER in aspirin users:
"Cancer was the major contributor to the higher mortality in the aspirin group, accounting for 1.6 excess deaths per 1000 person-years. Cancer-related death occurred in 3.1% of the participants in the aspirin group and in 2.3% of those in the placebo group (hazard ratio, 1.31; 95% CI, 1.10 to 1.56)."
nejm.org/doi/full/10.1056/N...
I do not know if it applies to prostate cancer in particular, but we all may want to avoid aspirin until we know more. There will be a longer f/u in the future. It also had no statistically significant effect on heart disease, but DID cause major hemorrhagic bleeding:
nejm.org/doi/full/10.1056/N...
You may have missed this prospective randomized trial of aspirin. It was small, and only up to 2 years of follow-up, but it found that:
"Our data do not show that aspirin or levofloxacin help to decrease the incidence of prostate cancer occurrence, delay castration-resistant prostate cancer transformation, or reduce tumour-associated death. "
thelancet.com/journals/lanc...
Other observational studies show no benefit:
"There was no association between aspirin use after a prostate cancer diagnosis and lethal disease in this cohort of prostate cancer survivors."
ncbi.nlm.nih.gov/pmc/articl...
"We found no evidence of an association between low-dose aspirin use before or after diagnosis and risk of prostate cancer-specific mortality, after potential confounders were accounted for, in UK prostate cancer patients."
"We found no evidence of an association between low-dose aspirin use before or after diagnosis and risk of prostate cancer-specific mortality, after potential confounders were accounted for, in UK prostate cancer patients."
link.springer.com/article/1...
"A HIGHER proportion of [aspirin] users (63.5%) and other NSAID users (61.2%) had PC compared with nonusers (41.9%). Clinically significant PC was MORE common among [aspirin] users (34.9%) compared with other NSAID users (20.0%) and nonusers (20.9%).
goldjournal.net/article/S00...
'We found no protective effect of aspirin, statins or antidiabetics in terms of risk for any PCa or high-grade PCa. Use of any statins was associated with an elevated risk of being diagnosed with high-grade prostate cancer."
ejcancer.com/article/S0959-...
"The post-diagnostic use of aspirin is not associated with a decreased risk of prostate cancer outcomes. Increased risks were restricted to patients initiating these drugs after their diagnosis, suggesting a noncausal association."
jurology.com/article/S0022-...
Inflammation is a very complex phenomenon. For prostate cancer, it seems that less aggressive forms put out more pro-inflammatory cytokines, whereas more aggressive forms put out more anti-inflammatory cytokines. This may be the reason for the equivocal findings. There may be some subgroups (possibly those on active surveillance) who benefit from aspirin. There may be other subgroups (possibly those with advanced PC) where aspirin may hasten death. Until we know more, caution is advised.
So much info. From my own experience, I've taken a lot of aspirin for sinus headaches for many years. I still got stage 4 pc. Not taking it now. Just glad to see that many are looking for a cure or treatment to slow this monster down.
Same experience. I got migraine as a child. And in the far outback of the Namib desert the only pill was Aspro. Have been a aspirin/paracetamol powder druggie my whole life - and end up with stage 4.
I do think more studies may show better results on some stuff like Voltaren.
The above study took all that into consideration:
"Aspirin improves outlook by 20–30 percent"
"To investigate the role of aspirin in cancer treatment, Elwood and colleagues LOOKED AT 71 STUDIES, which summed up over 120,000 people who had been diagnosed with cancer and started taking aspirin in addition to their treatment.
TWO INDEPENDENT REVIEWERS ASSESSED THE ELIGIBILITY OF THE STUDIES and examined the number of cancer-related deaths, the incidence of metastases, and the mortality from other causes among people in the aspirin-taking group.
"Large-scale research finds that a daily intake of aspirin halves the risk of gastrointestinal cancers."
The researchers then compared these data with those of approximately 400,000 people who did not take the drug.
OF THE STUDIES INCLUDED IN THE ANALYSIS, 29 examined cases of colorectal cancer. In addition, the researchers focused on breast cancer, which featured in 14 studies, and prostate cancer, which was the subject of 16 studies.
Overall, the analysis revealed that the chances of surviving a cancer diagnosis were 20–30 percent greater among people who took aspirin compared with those who did not. This was true at any given point after receiving the diagnosis."
"Evidence clearly shows a chemopreventive effect for aspirin and other non-steroidal anti-inflammatory drugs [...] on colorectal cancer and probably other cancer types."
Patients should have access to the evidence
The authors concede some limitations to their review. For instance, they write that the studies reviewed are purely observational and some of them did not find any benefits to taking aspirin.
However, Elwood and colleagues conclude that the findings "merit wide discussion regarding whether or not it is adequate to justify the recommendation of low-dose therapeutic aspirin" in the treatment of cancer.
"Patients with cancer should be given the evidence now available and be helped to make their own judgment of the balance between the risks and the benefits of daily low dose."
"All patients should consult their [physician] before starting new medication," adds the researcher."
Unlike ASPREE, this was just an observational study that can safely be ignored.
asprin is used for guys who have possible heartatach not pcancer who the shit told u that? there has been no proof that was true or everyone would be eating trees. heeeeeeeeeeeeeee
charli
exactly CM. I wish we would stop putting such stupid things on this site, it does nothing but fuel poor decision making on the parts of those who lack the expertise etc. and believe what they read, IE want to get cured when that is NO longer possible, want to take the easy route-when that too is NO longer possible.
Daryl, can we not screen some of these things in some way, i.e. maybe a separate section started that has all of these in one area, so it lessens the spread of such trash?????
There is still NO cure for advanced prostate cancer, the treatments that keep one alive are tough and have major impact on all areas of one's life. That gents, is the fact of the matter of having advanced PC!!!!!! NOTHING will change that path-at present and in the near future.
No one said it will cure you! No one said you should do it -- if posts like that offend your tender heart -- don't read them!
Personally I hope everyone on here posts EVERY thing they find that they think may possibly benefit any one of us and let each of us evaluate it for themselves. That is the main reason most of us are on here. -- If not, I want to find a site that will have the reporting of the many supplemental treatments others have tried so I may try them or not -- too. Like many other things Aspirin shows clinical evidence of possibly slowing the progress (otherwise they wouldn't be running these tests). I had been told to take low does Aspirin by my doctor for this very reason. "Little to no downside and likely to help slow cancer spread".
Just so you know I was told by no less than 6 doctors -- -- ADT doesn't extend overall survival -- ADT doesn't cure cancer -- ADT likely will speed the cancer to morph into a highly aggressive type in (on average) 2 years -- ADT causes CV and bone weakening, weight gain, and may not even slow progress at the end of the day -- M D Anderson RO, MO and referring MO said ADT kills about 3% of the easy to control cells -- does not effect cancer T cells. And said second line ADT drugs kill an additional (approximately) 8% of the ease to control (temporarily) for a combined 11 or 12% temporary benefit. - Every CO I have talked to said to delay as long as possible ADT unless taking with another treatment simultaneously.. But everyone races down to get it -- as if it is the do all -- to end all. LOL
It's funny seeing some folks get in an uproar if someone simply posts clinical trial results on here – that they don’t happen to agree with--- and wanting them “screened” for doing it??? --- LOL
They, on the other hand, are allowed to make personal swipes at others for simply posting trial results and then call for screening …LOL
billyboy3
“Daryl, can we not screen some of these things in some way, i.e. maybe a separate section started that has all of these in one area, so it lessens the spread of such trash????? "
And: charlesmeyers1964
"who the shit told u that? "
I told you who told me -- 2 of my doctors and 71 studies:
they should stick with there oncologist or urologist and leave the rest alone. if they want lup-177 and fly to Europe then do so its only $$$ and how much longer will u live for the cost. we were put on this earth for a time, GOD will determine when,how,why and when. stop do the best u can and move on. forget for a 1.000 dollars more one lives another wk. sorry who really gives a shit when the time is go with it, is MY personnel thinking. most likely not people want to hear but there is NO cure at this time. when there is we all well hear about it. some might be lucky and live, others will not.
charlie
Well doing something right 😜😜 taking aspirin for the high blood pressure that came along with 2 years of Xtandi 😀😀😀
I read about the cholera vaccine and dosage is prescribed for 18-64 year olds. Anyone know why it's not approved for folks older than 64? Seems like ageist discrimination to me. Hah!
There are some ongoing clinical trials that involve aspirin.
NCT03103152A study to examine the effectiveness of aspirin and/or vitamin D3 to prevent prostate cancer progressionProstate cancerRate of patient recruitment to a randomized chemoprevention study in men enrolled on an Active Surveillance program for prostate cancer. Time frame: 18 months. University Hospital of Wales, UK (and 5 more)
NCT00316927
Dexamethasone, aspirin, and diethylstilbestrol in treating patients with locally advanced or metastatic prostate cancerProstate cancerProstate‐specific antigen (PSA) responseBristol Haematology and Oncology Centre, UK (and 14 more)
NCT02420652
Metformin hydrochloride and aspirin in treating patients with hormone‐dependent prostate cancer that has progressed after surgery or radiation therapy. Recurrent prostate cancer. Change in stable PSA rates after 6 months of metformin hydrochloride and aspirin or placebo therapy in patients who have received 4 months of open label treatment [Time frame: baseline to up to 6 months].Rutgers Cancer Institute of New Jersey, USA
NCT01428869The effect of combination statin, acetylsalicylic acid and dutasteride use on prostate cancer—a subanalysis of the REDUCE trial. Time frame: 4 yearsUniversity Health Network, Canada.
Thanks to all for the information. And also the entertainment. Luckily I had already taken my chill pills for the day. I must now gird my loins for the Patriots and the Rams. Well, dammit, I'll gird something. Enjoy.
Bumper stickers should read "Eat a tree and save a Patient".
Good Luck, Good Health and Good Humor.
j-o-h-n Sunday 02/03/2019 5:55 PM EST
Not what you're looking for?
You may also like...
Case of stage 3 PCa patient that chose plant based diet
Stewart D Rose & Amanda J Strombom, 2020. "Stage 3 Prostate Cancer Treated with a Plant-Based Diet...
One of my 20 something yr pt gave me St Peregrine - Patron St for Cancer victims. Have it up at the front desk
If you're inclined, say a lil Prayer for the Brothers here and their Caregivers...
Newly Diagnosed Metastatic Prostate Cancer
62 years old diagnosed with Stage 4 metastasized to both hips, spine, and ribs. I have yet to find...
SSDI denied
I thought that having a terminal illness diagnosis would have qualified me for SSDI, social...
Five Year Survivor - WooHoo!!
This month I am a 5 year survivor at age 70 after my initial very metastatic diagnosis at age 65...
Ideas on how to cope with anxiety/depression?
Now also diagnosed with bladder cancer!!
Prostate cancer and pain
Treatment naïve and clinical trials
Asymptomatic PC?
