Scientists identify gene responsible for spread of prostate cancer

[Moespy]

This looks promising.

A Rutgers study has found that a specific gene in cancerous prostate tumors indicates when patients are at high-risk for the cancer to spread, suggesting that targeting this gene can help patients live longer.........

medicalxpress.com/news/2019...

[NPfisherman]

Nice find...Thanks for posting... a way to stop the spread, genetic targeting, treatment sensitizers, improved chemotherapy, immunotherapy, and new radiation therapies...working on ways to stop castrate resistance...there is hope, folks...

Keep fighting,

Fish

[Moespy in reply to NPfisherman]

Here is a link to the study cited in the article.

nature.com/articles/s41467-...

[NPfisherman in reply to Moespy]

Looks like MCTP-39 has real potential to slow tumor progression. From article:

Since we found that this inhibitor was well tolerated in vivo (Supplementary Fig. 4), we evaluated the effect of MCTP-39 on tumor growth of human prostate cells in vivo by establishing DU145 xenografts (Fig. 7c–f). We found that DU145 xenografts treated with MCTP-39 had a significant decrease in tumor volume (n = 14 vehicle-treated and n = 15 MCTP-39-treated; p < 0.001, two-way ANOVA; Fig. 7c, d).

Enough mouse testing, set up the phase 1.......

Fish

[Moespy in reply to NPfisherman]

I will be keeping my eye out for CT's on this one. Hope it happens sooner than later.

Jim

[NPfisherman in reply to Moespy]

Keep your eye on TAS 3681 and TRC 253 as well...... both are drugs that may block/stop wild or mutated AR leading to castrate resistance...3rd generation ADT.... Phase 1/2......The question will be can it stop it permanently, and if so...it could be a real game changer...

[Moespy in reply to NPfisherman]

It may be my unconscious positivity (or ego) but I really believe I will make it to the cure one day. As long as they keep delaying progression I, and many of us, may make it to that cure. Thanks for the info.

Jim

[NPfisherman in reply to Moespy]

Hoping to do the same, amigo...Hang around for the cure...some of these drugs will help slow Pca down, or regress it......I follow my diet, exercise, sleep...and be proactive regarding treatment--asking to be put on metformin next week...

Best of luck to us all,

Fish

[j-o-h-n in reply to Moespy]

Thanks, that's exactly what we need, MO SPYING...

Good Luck, Good Health and Good Humor.

J-o-h-n Sunday 01/20/2019 2:02 PM EST