PTEN Loss gene and Advanced Prostate Cancer

[paige20180]

My husbands genetic tests are back from Foundation One and he has a concerning mutation PTEN. He tested negative for BRAC, KRAS. If anyone has the same gene with any insight, we’d greatly appreciate your help. Thanks!

[Tall_Allen]

It's very common with APC. Unfortunately, there are no known therapies for it.

nature.com/articles/nrurol....

Clinical trials are investigating carboplatin, and AKT inhibitors (Ipatasertib, afuresertib) for it.

[Hidden]

PTEN loss is very common and the problem is it activates the P13K/AKT resistance pathway.

Here's a table of clinical trials:

molecular-cancer.biomedcent...

Here is a table of drugs being tested:

molecular-cancer.biomedcent...

And an article on the subject:

molecular-cancer.biomedcent...

You can also do a search at clinicaltrials.gov for more up-to-date information regarding clinical trials

[jdm3 in reply to Hidden]

Re P53, P13, etc...

In addition to sulforaphane ..... PEITC is an isothyocianate found in cruciferous vegetables - think watercress

jeccr.biomedcentral.com/art...

Luteolin

ncbi.nlm.nih.gov/pubmed/233...

Apigenin

ncbi.nlm.nih.gov/pubmed/275...

Apigenin (APG; 4',5,7,-trihydroxyflavone) is a naturally occurring plant flavone abundantly present in common fruits and vegetables such as grapefruits, plant-derived beverages, parsley, onions, chamomile, oranges, tea and wheat sprouts. The most common source of APG consumed as a single ingredient in herbal tea is chamomile, prepared from the dried flowers of Matricaria chamomilla. Recently, APG has been increasingly recognized as a cancer chemopreventive agent. Numerous studies have explored the possible cancer chemopreventive effect of APG based on its potent anti-oxidant, anti-mutagenic, anti-inflammatory, anti-viral and purgative effects. The promising role of APG was summarized in various cancers including PCa.

[Shanti1]

Hi- There is some preliminary evidence that sulforaphane from broccoli family plants may target PTEN (see references below). Many forum members take sulforaphane containing broccoli supplements based on this and other evidence. You might consider adding in a sulforaphane containing supplement at higher doses or adding broccoli sprouts to the diet as they contain a high amount. In the absence of other ways to target PTEN, this may be a consideration.

Broccoli, PTEN deletion and prostate cancer: where is the link?ncbi.nlm.nih.gov/pmc/articl...

Traka MH, Spinks CA, Doleman JF, et al. The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a PTEN null preclinical murine model of prostate cancer. Mol Cancer. 2010;9:189.

Qi M, Anderson AE, Chen DZ, Sun S, Auborn KJ. Indole-3-carbinol prevents PTEN loss in cervical cancer in vivo. Mol Med. 2005 Jan;11(1-12):59-63.

[paige20180 in reply to Shanti1]

On it Shanti!

[tango65]

There are clinical trials with AZD8186 which could work in patients with PTEN mutations:

clinicaltrials.gov/ct2/show...

They are recruiting at the MSKCC in NY, at the MD Anderson in Houston and at JHopkins in Baltimore.

Memorial Sloan Kettering MonmouthRecruiting

Middletown, New Jersey, United States, 07748

Contact: Site Public Contact 212-639-7592

Principal Investigator: Alison M. Schram

M D Anderson Cancer CenterRecruiting

Houston, Texas, United States, 77030

Contact: Site Public Contact 877-632-6789 [e-mail]

Principal Investigator: Ecaterina E. Ileana Dumbrava

Johns Hopkins University/Sidney Kimmel Cancer Center Recruiting

Baltimore, Maryland, United States, 21287

Contact: Site Public Contact 410-955-8804 [e-mail]

Principal Investigator: Catherine H. Marshall

Best of luck.

[Hidden in reply to tango65]

Good find. I went through all the clinical trials looking for P13K inhibitors, AKT inhibitors and M-tor inhibitors. I couldn't find any that were active and recruiting.

[pjoshea13]

Paige,

Some old posts that touch on PTEN. You might want to search on <nalakrats pten> too. -Patrick

See: healthunlocked.com/advanced....

healthunlocked.com/advanced...

healthunlocked.com/advanced....

healthunlocked.com/advanced...

healthunlocked.com/advanced...

healthunlocked.com/advanced...

healthunlocked.com/advanced....

[paige20180]

My husband, entire family and I are incredibly grateful to all of you!

May I ask another question.. does anyone know if having PTEN loss effects Lu177 treatment?