Hi, hope everyone is doing well. Good thoughts and prayers to all fighting the beast. I have a question for those of you that had been on Xtandi and had significant side effects. My father began Xtandi and after the 3rd week we saw significant mood change, depression and forgetfulness. The MO recommend we lower the dose to 3 pills a day. Since then my father is back! He still gets sleepy and tired but the mood, depression and forgetfulness has resolved. If any it’s very mild. I’m so happy, then again on the other hand how effective is it ? I’m worried because he didn’t have a significant decrease after using it for 1 month. His PSA went from 4.1 to 4.0. I guess since the double time was a month and his PSA didnt rise it’s working but .. how good is it really working if he is not taking the full dose? Any thoughts??