PSA rising

[firefox12]

To say I am not worried would be lying. My PSA has come down continually from over 10,000 to 312. Just before my fourth Docetaxel Chemo it went up to 383. Now just before my fifth chemo it has gone up again to 452. I don't understand why it is rising like this. My oncologist said it is less of a worry because of my baseline number of over 10,000 so the increases are not large for me. It has still worried them enough to repeat scans before end of my chemo. Any advice?

[Tall_Allen]

Good idea to get scans - PSA isn't always the best biomarker.

[charlesmeyers1964]

i've heard of no one alive with a psa of 10,000 count your blessings. i'm worried after 10 years and mine is 28. i have heard of anyone that high being alive and now its in 300 count your blessings and move on

[firefox12 in reply to charlesmeyers1964]

I don't think this is that helpful. I had urology problems for 5 years which went undetected as prostate cancer, despite numerous GP and hospital visits so I was left with this 10,000 PSA due to negligence. Thank god I was still alive after all that. This is the kind of subtext I get from Oncologists, that my PSA was 10,000 so an increase to 452 is not that high. But it is high, and shows the disease is still prevalent. How can I move on? I agree with others here, that I'm happy for scans before any other decisions. They want to get maximum benefit out of chemo so still going ahead. MY ALP has continually come down to 94, so it is some comfort.

[George71 in reply to firefox12]

Have you looked into Dr. Bob ? Your case sounds right up his alley.

You can see his videos on his website -- he is in southern California area.

compassionateoncology.org/a...

[George71 in reply to George71]

compassionateoncology.org/v...

[j-o-h-n]

to firefox12:

"PSA from 10,000 to 312, then 383 and now 452". You hit the lotto... Go out and celebrate by taking your wife dinner (make sure she pays).

Good Luck and Good Health.

j-o-h-n Thursday 09/20/2018 5:59 PM EDT

[ctarleton]

Almost 5 years ago my PSA roller coaster ride started at 5,006 and then went down to 1.0 on Lupron for a couple of years, and then back up to 95, and then back down to 1.2 when Xtandi was added almost 2 years ago. I agree with Tall Allen about getting other evidence of actual disease status from some scans. Alkaline Phosphatase trends monitoring could be helpful, too.

Charles

[Ldb01]

I am shocked the hear these high PSA numbers. My husband’s last count was 48 and its been a rollercoaster ride. Dr’s telling us its far too high. Saw a professor the other day who said my husband’s case is one the less extreme he has dealt with ? His one patient had a PSA of 2000 and dropped to 1000 after ACT 225.