What next when Zytiga fails?

[Chugach]

Diagnosed at 46; stage 4 Gleason 9/10; chemo and radiation, Lupron; surgery was not an option. 1st recurrence 9 mo after chemo/rad hell - moved to bone more targeted radiation (game of whack-a-mole). 1000 mg Zytiga and 5 mg pred for 11 months now. Now 48 and 2 1/2 years onto this twist in the trail. I’m seeing slight signals my PSA may be rising again. What’s next when Zytiga fails?

[MarcoGlenn]

Hi Chugach. I was also diagnosed with Stage 4 at 47. My first PSA was 1882 it was all in my lymph system and most all my bones. I have had chemo, Provence, hormone shoot every 6 months, casodex every day. Keep a good attitude and keep fighting. Sorry I can not post more now. Just wanted you to know there are others like you out here. I will try to post more latter after work.

[Dalph87]

Xtandi, Provenge (Immunotherapy), Radium 223 (Xofigo) if in the bones, Chemo again with Docetaxel and Jevtana which sometimes can even re-activate for a while the effects of Zytiga and Xtandi, just get a PET PSMA scan for more targeted therapies and drugs and ask your MO for Lutetium 177 (Lutathera), also you can try BAT but I heard it doesn't work for everyone and might even cause some troubles, so it's risky.

Dad just started Zytiga 3 months ago and takes it with prednisone and Lupron shots every 3 months.

So far so good, he had surgery, Casodex and pre-chemo with Docetaxel, was able to tolerate everything, has currently no side effects and feels pretty well.

Keep fighting, also ask your MO for clinical trials, there's a lot of stuff available out there, new meds are coming out everyday.

[vandy69]

Good Thursday Afternoon Chugach,

Been in this battle for six years (please see bio for complete treatment history).

Have you had a Guardant360 liquid biopsy (takes 2 vials of blood). I have had 4 and 1 showed an ATM defect permitting Dr. Charles "Snuffy" Myers to prescribe Lynparza, a PARP inhibitor, which worked for about 9 months.

Most recently Docetaxel/Carboplatin chemo reset cancer cells and a rechallenge with Xtandi has worked for 5 months, even though it had failed back in 2015-16 after 12 months.

Best wishes. Never Give In.

Mark, Atlanta

[CalBear74]

You have received excellent suggestions above but no mention of complementary medicine (natural supplement) strategies compatible with leading edge oncology. Here are some thoughts to consider:

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