Spoiler Alert: Since the diet and supplement wars have often been fought in this forum with no one but the true-believers convinced by the arguments presented, I thought I would dedicate this post to the people who may agree with me. Of course others are free to voice their disagreement, but be warned in advance, I won't reply them.
Now that our Guru has left us for a Walkabout to frolic amongst his brethren crocodiles, to renew his spiritual and vital forces, apparently many of us are loathe to take up the cudgels in defense of diet and supplements for fear of being browbeaten by bullies who support the other side of the issue, being told how stupid and ignorant we are. Conserquently, I thought I would offer a little support for we, the unenlightened.
First of all, there is the question of diet and PCa. From what I have read, according to available studies of the diets of the many traditional populations ( before the “fast food invasions changed the eating habits of people), probably the best advice we can follow is, as a paraphrase of the popular song goes, “You have to accentuate the [flora] and eliminate the [ fauna-tive]...and don't mess with mister in-between.” Don't overeat, limit your caloric intake as much as possible and exercise—aerobic and resistance. As many of us know, often this is not enough, but we only have so-much control over our lives. We do what we can.
Secondly, many of so-called long term scientific studies involving thousands of people are probably wrong. Example, the wrong forms of Vitamin E and Selenium were used in the SELECT study. There is a good chance that the organic forms of Selenium--the form of selenium used in the SELECT study was l-selenomethionine at a dose of 200 mcg-- may not have been enough but also a form that some research studies indicate may be inferior to the in-organic form, Sodium Selenite. “Selenite-induced p53 Ser-15 phosphorylation and caspase-mediated apoptosis in LNCaP human prostate cancer cells.” ncbi.nlm.nih.gov/pubmed/152....
Vitamin E, for example, may have been another incorrect choice. Again, in the SELECT study, we know that the SELECT trial used non-natural and chemically-derived vitamin E (dl-alpha tocopherol acetate) at a dose of 400 IU per day. Any time you see an “l” after the “d” in a vitamin E product throw it in the trash where it belongs. But let's ignore this for the moment. We know that there are eight natural forms of vitamin E, 4 tocopherols (alpha, beta, gamma, and delta) and 4 tocotrienols (alpha, beta, gamma, and delta). While d alpha tocopherol is the most common form of vitamin E in dietary supplements, it is actually gamma tocopherol that is the most effective one. Unfortunately, the more Alpha Tocopherol one takes, the less Gamma Tocopherol becomes available: the tocopherols compete with one another for absorption. And, to further muddy the waters, recently we have learned that it may be the Tocotrienols, in fact, that are the most most effective with the Delta faction being the most important. In short, the SELECT study may have been flawed from the get-go by the ignorance of the supplements, on the part of the researchers, which they were studying.
Thirdly, one must really be careful re all of the current hoopla over ROS :
1- Chronic oxidative stress promotes aging and metastatic spread:
In last years, the “Stress and Cancer” laboratory has identified two new molecular players of the oxidative stress response, the miR-200 family of microRNA and the transcription factor JunD. We showed that a chronic oxidative stress accelerates aging through accumulation of HIF (Hypoxia-Inducible Factor) and modulation of insulin signaling (Gerald, Cell, 2004; Laurent, Cell Metabolism, 2008).
Consistent with the fact that cancer is one obvious pathology observed in elderly, we discover that persistent ROS increase tumour development and metastatic spread, by deeply modifying tumour micro-environment. Conversion of fibroblasts into myofibroblast result from ROS-mediated accumulation of pro-angiogenic (HIF) and pro-inflammatory (SDF-1/CXCL-12) components. These studies established that HER2 tumours, which are characterized by a high rate of nodal metastases, exhibit a high proportion of myofibroblasts and a signature of oxidative stress (Toullec, EMBO Mol. Med, 2010; Scholer-Dahirel, Cell cycle, 2013; Costa, Sem. Cancer Biol., 2014).
Remember science if falsifiable, always subject to change!