Log in
Advanced Prostate Cancer
7,158 members7,144 posts

PSA stable but Cancer spread to liver

Hello all,

My dad was diagnosed with advanced prostate cancer in May 2016. He is currently on Zytiga since Aug 2017.

He had few months ago spot radiation on some of his bone mets and he had a very good response. Bone mets were reduced, PSA dropped from 2.8 to 0.7 and stable up to now. But the MRI from early this week shows that cancer spread to Liver. Doc recommended 3 cycles of Jevtana at first. And he said he is not taking PSA as a reference anymore, since it spread with stable PSA. Any one had such experience in the group? What could you recommend?

12 Replies
oldestnewest

I think your Doctor suspects Neuroendrocrine Pca cells--that do not give off the PSA, because of the finding of it in the Liver. So you wind up monitoring the tumor and its size with scans--while being treated, as opposed to with PSA tests. This is my guess. Ask the Doc. if he suspects NE Pca.

Nalakrats

1 like
Reply

Thank you Nalakrats! I am gonna ask about the Neuroendrocrine cells.

And if this is the case, what would be the best medication/therapy? Any ideas other than Jevtana? Or is the the best way to go.

Reply

Chromogranin A-Blood Test can be an indicator---Platinum based Chemo is usually front line Treatment. There is a paper on the use of Concentrated 7X BIRM, as being able to prevent production of the enzyme Hyaluronidase--which has been identified as the Transporting agent that the NE Pca cells hitch a ride on to get to bone and soft tissue.

There is a lot on controversy here with some members, demanding double blind studies, on non=drug materials. But there is no evidence of Death from BIRM. Univ. Of Miami Medical School has been granted NIH Monies, from the Dept. Of Defense to further Study BIRM, and its affects against Pca. This is a pretty big deal. And it has been found that the Medical School has a history of treating Pca with BIRM--going back a number of years---but their results are not public.

Anyway--I am just reporting--and not a Doctor.

Nalakrats

1 like
Reply

Since you father has had bone mets, bone alkaline phosphatase may be a better marker as the disease progresses. Also radiographic evidence becomes more important. PC may sometimes put out less PSA as it progresses.

1 like
Reply

Thank Allen, I wrote down. I ll ask about the bone alkaline ohosphatase.

Reply

Yes, I had this experience with my husband. His PPSA was very low when his cancer spread into the liver. The reason why PSA is no longer an indicator then is because the cancer has changed and most likely become an endocrine tumor. My husband was put on Carbo Platin for six and then again four cycles. Generally speaking, because the liver is such an important organ, it is a very serious diagnosis. Good luck with the treatment. Keep us posted please. Mel.

2 likes
Reply

Thank you Melanie. Yes, I did not like it all when I heard about the liver involvement.

I also hope the treatment will work perfectly.

Reply

Good Friday Morning Shumaf,

I have been in this battle for almost six years (please see bio for complete treatment history).

When diagnosed with liver mets in 9/17, began chemo with Docetaxel/Carboplatin for 6 cycles.

PSA dropped from 10.8 to .4 and liver lesions became smaller and less distinct. Better outcome was that chemo reset cancer cells and/or AR7- Splice Variant and rechallenge with Xtandi (which failed after 12 months in 2015-16) is worked again. God's miracle with Xtandi has kept PSA stable at .7 for 3 months!

Have liver MRI and blood work next week 🙏

Best wishes. Never Give In.

Mark, Atlanta

2 likes
Reply

Good morning Mark,

Thank you for your message. This is encouraging.

I hope you will have wonderful results from your next MRI and blood work.

Do you know how the docs decides which chemo drug to go with?

My dad has already had as first line Docetaxel treatment. Now the Doc says, Jevtana (no carboplatin). Is this kind of a standard treatment for second line? I read that many people had a combo of Carboplatin with Jevtana or Docetaxel for Liver mets. I'm wondering what is the decision criteria of Carboplatin; side effects, efficiency, other mets?

Best wishes!

Reply

Talk with your doctor about embolization with SIR micro-spheres.

verywellhealth.com/sir-sphe...

sirtex.com/us/patients/abou...

1 like
Reply

Hi sharif ask if it’s possible to do a liver biopsy to check whether the cancer has changed to become neuroendocrine. Carboplatin seems to be one of the common modalities used for neuroendocrine cancer - often combined with jevtana. also now they are using lutetium 177 octreotate for NE cancer so you could check that out as well.

1 like
Reply

The Doc said that he considers Carboplatin and Lutetium 177 as backup plan. He thinks that Jevtana alone would work now. I hope it works very well. It will start in 2 weeks.

Reply

You may also like...