TMI Overload Paralysis , ATM gene defect, and its BT radiation therapy in 10 days.

[sammamish]

So all scheduled for BT therapy(90 days post DX with gleason 9, 15 PSA, & lymph involvement). Just learned I have a germ cell defect on ATM gene (heterozygous in every cell in my body). So that's great if you want to irradiate cancer cells, but not so great for healthy tissue which has a hard time repairing DNA already(i.e. increased overall risk of cancer).

Anyone have any experience with radiation "sickness", acute effects, or germ cell mutations. I am thinking it may not be wise to ionize now. Maybe RP , PARP and hormones instead? Damn twists and turns and I have barely started(Caso & Lupron, and S*+x! ton of supplements.

[Tall_Allen]

You should cancel the radiation. It's lucky you found out about having this rare germline defect before getting radiation.

[sammamish in reply to Tall_Allen]

Hi Tall, so not a lot of research on this topic. came across this meta analysis. ncbi.nlm.nih.gov/pubmed/274... . Basically says a 1.5 risk of short term toxicity compared to the "normal" risk profile and a 1.2 HR for long term affects. So I guess this means if Brachyboost was done and has a 3% short term toxicity rate, then that would bump up to about 4.5% right?

[Tall_Allen in reply to sammamish]

That is for one SNP on one allele, the OP carries two. They didn't evaluate urinary toxicity, which is the largest source of toxicity. Brachy boost has a 19% chance of late-term urinary toxicity, which is high from the start. ATM defects also carry high rates of fistulas and secondary cancers. No one with a germline ATM defect has any business getting radiation. He should also avoid any direct exposure to sunlight.

[sammamish in reply to Tall_Allen]

Did you get the 19 percent out of the meta study or somewhere else? Also, to be clear, I have the single allele defecti.e , one normal and one truncated. Honestly when I try and read the study I can barely make heads or tails of it.

[Tall_Allen in reply to sammamish]

I got that from the ASCENDE-RT study.

[sammamish in reply to Tall_Allen]

Ok thanks Allen