Zytiga followed by Docetaxel followed... - Advanced Prostate...

Advanced Prostate Cancer

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Zytiga followed by Docetaxel followed by Zytiga again?

EdMiller profile image
6 Replies

I have read at least 3 times (I think) on this website that some claim that Docetaxel has been known to help with a successful re challenge with Zytiga. But I haven't been able to find anything in the literature that provides any information about this at all. Can anyone provide a reference for me on this topic? Zytiga worked 2 years for me very successfully, lowering my PSA considerably until it finally stopped working. I also had minimal side effects (in fact, none of which I was aware) with Zytiga. Since then I have had 6 doses of Docetaxel -- one every 3 weeks -- my last treatment was this last week. My PSA stayed about the same on Docetaxel. I certainly would be interested in trying Zytiga again (and talking to my oncologist about it) if there is evidence that Zytiga might be effective again after Docetaxel chemo treatment.

6 Replies
Tall_Allen profile image

I would characterize it as more a hint than evidence. It was only a small pilot study at JH, but in a few men (6 of 14), the AR-V7 splice variant reverted from positive to negative after taxane therapy. It certainly seems worth a try.


EdMiller profile image
EdMiller in reply to Tall_Allen

Thank you so much, Tall_Allen.

cesanon profile image

Docetaxel has a lot of side effects. And they feed it into you through a port they install in your shoulder.

vandy69 profile image

Good Sunday Morning EdMiller,

I have been in this battle for almost six years (please see bio for complete treatment history).

I had a 12 month run with Xtandi from 2015-16 after a prior 18 month run with Zytiga. Both of them failed.

Had 6 cycles of Docetaxel/Carboplatin chemo ending 1/9/18 (had a good response to chemo--PSA dropped from 10.8 to .4) and we decided to try Xtandi for a second time, as PSA was rising. Miracle of miracles, it has worked for the past 2 months! Do not know how long this may last, but praying for an extended chemo break.

Best wishes. Never Give In.

Mark, Atlanta

dadeb profile image
dadeb in reply to vandy69

That’s fantastic!

EdMiller profile image
EdMiller in reply to dadeb

Vandy69, thanks for your reply. Very interesting.

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