Lytic lessions?

[BigM62]

I was diagnosed with advanced stage 4 disease via bone tumor biopsy. So because i never had a prostate biopsy, i never recieved a Gleeson score. So finally i was curious today to ask my MO for copy of biopsy report: high grade prostate adenocarcinoma. No suprise there. But what i missed before was that the biopsy was done on a "lytic lession" on T12. My understanding is that prostate tumors are extremely rare to by lytic. Is it possible that they used it as a general term?

[YostConner]

According to the National Cancer Institute, A lyric lesion refers to destruction of an area of bone due to a disease process, such as cancer. I had never heard this before, but it's sure what my lesions do. I have had at least one pathological rib break.

[pjoshea13]

In normal bone, remodeling is common; osteoclasts break it down & osteoblasts build it up. Most PCa is osteoblastic. A bone scan shows up white because of the high density of cells. Dr. Myers has pointed out that most of the excess cells are actually normal cells.

In breast cancer, bone mets invariably show up black on a scan because they are osteolytic (osteoclastic). This is uncommon in PCa but can occur.

A 2015 paper [1] asks:

"Should prostate cancer be considered as a differential diagnosis in patients with osteolytic bone lesions?"

Do you have lytic lesions other than at T12?

-Patrick

[1] europeanreview.org/wp/wp-co...

[BigM62 in reply to pjoshea13]

Thats my question as well. I just caught this on biopsy. I will need to go back and read my MRI report to check. Im super interested. I also read somewhere that lytic lessions are more closely related to nueroendocrine prostate cancer. My PSA is on the low side (dx at 11, but month before was 3.1) but bone biopsy report clearly says adenocarcinoma with promiment nuclei and stains were positive for adenocarcinoma (which i understand markers and stains to be different between the 2). Anyway, i will go back to MRI report. I have many many spine mets.

[Dan59 in reply to pjoshea13]

Patrick, Excellent information, I wish we had a way to save this to the site . Thank You

Dan