Sharing Genomic Mutations Panel with hopes someone will understand it and explain it…

[Shorehousejam]

These Results are from the biopsy samples from when my husband was diagnosed this past July 2022,

PSA 942.40, Gleason 8, Ductal w/ crib from architecture,

4 cores out of 15, 44% Ductal PCA average from 4 cores, more info in bio

3 Lytic Lesions, Pelvic Lymph Node Involvement, Thoracic Lymph Node ,

[Shorehousejam]

Please look at percentages, Tall_Allen What do you think?

[Tall_Allen in reply to Shorehousejam]

I don't know why you think percentages help?

[Shorehousejam in reply to Tall_Allen]

Are the percentages out of a 100% do you know?

There are gene mutations that are cancer bio markers and it’s sadly distressing….the other reason we are looking as the other issue is the sever plaque psoriasis and the inhibitor my husband must use, either a pde4 like Otelza, which certain research shows pde4 drives, TP53, HRAS, WT1…and possibly using a biologic like a IL-23.

I would think a IL-17 would be out of question…but they are all TNF

Suppressants

[Seasid in reply to Shorehousejam]

I think Shooter said that we need at least a percentage of 30 % of the actionable mutations in order to be useful. Can you contact shooter? I am just a Postman. Shooter said that ones. And It made sense to me. Maybe I misunderstood something.

[Shorehousejam in reply to Seasid]

Thank you, I will give it a try

[Shorehousejam]

 Seasid I got the percentages, so what do you think?

[Seasid in reply to Shorehousejam]

What is the percentage?

[Shorehousejam in reply to Seasid]

They are in the photo

[Seasid in reply to Shorehousejam]

Thanks.

[Tall_Allen]

As so often is found, there is nothing currently useful there, unfortunately.

[Shorehousejam in reply to Tall_Allen]

Isn’t that something after decades of research,

The most important thing, the cell, nucleus and the reception of therapies that are needed to beat cancer, and gene mutations must be dealt with to modified these therapies so they work in and with the individual’s DNA

[tango65]

There is a mutation in the TP53 gene which usually favors cell replication. PC with this mutation may respond to BAT (Bipolar androgen therapy).

ncbi.nlm.nih.gov/pmc/articl...

BAT is experimental but there are clinical trials

clinicaltrials.gov/ct2/resu...

and most oncologists know the protocol and they could use this treatment.

[Shorehousejam in reply to tango65]

Well, we asked my husband’s MO at a major Research Teaching Hospital in NYC and he said it doesn’t work….we don’t know what to think about his comment

[tango65 in reply to Shorehousejam]

That is correct for a general population of patients but it may work in selected patients depending on the mutations of the cancer. Cancers with PT53 mutations may respond to BAT therapy.

[Shorehousejam in reply to tango65]

Thank you

[tango65 in reply to Shorehousejam]

Best of luck.!

[Shorehousejam in reply to tango65]

You too