As you know a couple of weeks ago, I wrote an email to a Professor Lodi listed on the paper outlining a possible treatment modality involving Ursolic Acid, Curcumin & Resveratrol to treat cancer metabolism. I posted my letter here on this site. Well, for whatever reason (sabbatical, vacation, not interested, too busy, etc.), Professor Lodi has not replied as of 7/5. Not one to be discouraged so easily, I wrote an additional letter, similar to the one to Professor Lodi, but with important additions: my own extrapolation from some of the data provided into a formula that we might use. I have asked this other researcher, Professor Tiziani, whose name appears under "contact," for his input. I might add one thing: these people work for a public university, the University of Texas, which I assume pays their salaries and for at least some of their research work: NIH is also listed as a contributor to the grant that funded this paper. While they are not necessarily required to translate their work into terms we can understand nor provide any professional advice, they are receiving public funds and therefore owe us the courtesy of at least responding to the email and explaining why they won't or are unable to help us.
Dear Professor Tiziani,
You are listed as the contact person for inquires re your recent paper, the implementation of natural compounds in cancer treatment. I am a member of HealthUnlocked which is an open discussion forum on the Internet. We are mainly concerned with prostate cancer. Many of the members are in the advanced stage of this disease, so it is very important to them when they read articles about cancer treatment, especially ones citing the use of natural sources. The members are well-aware of the traditional allopathic treatments available to them. They are always interested in finding something from the natural realm which they may use to augment their current treatments. Your article is written, of course, for other scientists and researchers to read, not the lay public. The employment of scientific measurements to measure results is difficult for us to translate into measurements (mg, mcg, grams)more familiar to us). While we are very excited by some of the material presented in the paper, unfortunately, as it is written, we really are unable to apply much of the information in our own lives.
The only "hint" we have is "...AIN764-based diet containing 1.0% CUR, 0.2% UA and 0.5% RES."
Extrapolation of these figures, based on an average person consuming 4 lbs. of food a day would result in Curcumin= 1400 mg;
Ursolic Acie= 300 mg;
Resveratrol= 700 mg
These amounts, in combination, would provide a therapeutic effect. Without committing yourself to any "prescriptive" advice, could you say that the above percentages might fairly accurately translate your finding with mice and other lab work into a useful formula for supplementation? We really would appreciate whatever guidance you may provide to assist us in implementing some of the findings presented in your research paper.
Best of health,