Combination of Ursolic Acid - Resveratrol - Curcumin Stops PCa Growth

[gusgold]

This Could Be BIG News

Gus

nature.com/articles/s41698-...

[Dan59]

Thanks Gus, Resveratrol and Curcumin have long been known to be beneficial. One day I hope to read an article like this that tells of the finding of a cure for Cancer, I hope it is in the not to distant future.

[ctarleton in reply to Dan59]

Those dang lab mice get all the good drugs and supplements. The headline "Cancer Cured in Mice" would likely come first.

[Sisira in reply to ctarleton]

Ctarleton,

Very interesting! Well said! Mice, such a privileged species!

Classic humour, I can laugh for years until a Drug comes to cure us!

Thanks for your words.

Sisira

[paulofaus]

Boy, I have an advanced university education (albeit not in a scientific area) and I could barely understand a word of that. A conclusion from the authors would have been nice. Thanks Gus.

[Jayg57 in reply to paulofaus]

Translation : medicalxpress.com/news/2017...

[paulofaus in reply to Jayg57]

Thanks jay.

[rococo]

Where do hou get ursolic acid. I'm taken the other 2, resveratrol curcumin+ querecitin

[Jayg57 in reply to rococo]

vitacost.com. Search for ursolic acid.

Keep us posted about your clinical trial of one.

[paulofaus]

After reading the material, it seems that this combination starves cancer cells of Glutamine. There is a researcher in Australia working on a medication which does this very thing, see: acrf.com.au/all-cancers/new...

[Sisira]

Paul,

Throwing road blocks to the supply of various growth factors that support PCa growth is obviously a good strategy to mange the decease. This brief article is only "Good News" and does not contain sufficient specifics regarding the discovery. Nevertheless hope for a breakthrough from Australia.

Thanks for your contributions to the original post.

Sisira

[Kuanyin]

Great news but...(1) Again, how does one make the leap from test tubes & mice to Homo sapiens? We are told that "treatment with the natural compounds was started by switching animals to semipurified AIN76A-based diets containing 1.0% CUR, 0.2% UA, 0.5% RES or their combinations (all ad libitum). Great, how do we extrapolate to human diets and percentages? (2) have read somewhere that Ursolic Acid may be involved in muscle growth( "Ursolic Acid-induced elevation of serum irisin augments muscle strength during resistance training in men") however, this also includes raising levels of IGF-1 which, as we know, in turn, increases insulin and (3) Ursolic acid is not water soluble and poorly absorbed. What are we to make of this? While the curcumin-turmeric people have made great strides in increasing the bioavailability of these chemicals, there doesn't appear to have been a similar effort with ursolic acid.

[gusgold in reply to Kuanyin]

K,

You are right on. High does of ursolic acid are dangerous because it can cause the breakage of DNA strands..so the cancer dies an so do the health cells. I bought Organic Apple Extract which contains high doses of naturally occuring ursolic acid

Gus

[Kuanyin in reply to gusgold]

Great minds run in the same channels (or, Fools think alike). I did the same. I just purchased "Organic Apple Powder" on Amazon. I'll probably mixed it, 2.5 rounded teaspoons, with my oatmeal in the morning for breakfast and drinks at lunch and dinner. Added bonus, there is some fiber and vitamins. Most importantly, it would be hard to overdose on the stuff. To supply the therapeutic amount of ursolic acid, taking an average apple to be 100 grams, one would have to eat 11 apples a day to supply the therapeutic levels required for it to be effective: 1.4% of total food intake (please don't ask which one of the articles is the source of this information). 2.5 rounded teaspoons x3 of Organic Apple Peel Powder would be the equivalent to at least 7.5 apples. Note: I called Organic Apple Powder for the above breakdown: they didn't have the information at hand but will get back to me. My source was a provider of a similar product. Now, for the cocktail to be complete, we just need to fill in the numbers for curcumin and Resveratrol. Good luck with that. One final word: the Chinese are doing research with liposomal ursolic acid with results but also side effects. Since ursolic acid is not water soluble, I will mix my cocktail with a teaspoon of olive oil in a blender as I have habitually been doing with the curcumin.

[Neal-Snyder in reply to Kuanyin]

Maybe it's more feasible with holy basil? See Nalakrats above.

[Kuanyin in reply to Neal-Snyder]

The problem is standardization and the processes researchers use to get an anti-cancer effect: by the time the chemicals have gone through a rigorous purification process they are probably almost pure, while as far as I can see, the Holy Basil and Ursolic acid sold don't indicate any standardization. I have found a couple UA at 2%. One of the difficulties encountered by the researchers described in the article sent by Gus, is that to achieve anywhere near a therapeutic dose of many of the substances studied (some of them more effective than Ursolic Acid) is that the concentration of the nutrients needed to be effective was also toxic. However, there is also the issue of synergy: synergy probably reduces the need for high doses required by use of single substances. But the articles we read are couched in terms of ug ml and ug dl % in our blood over periods of time. How to use this information is problematic.

[Neal-Snyder]

Very helpful, Nal. Always happy to hear that I already have a particular base covered, & don't need to add to my big daily supplement intake.

BTW, Organic India's Tulsi (holy basil) tea is delicious!

Neal