I had some problems with lipid-soluble Simvastatin a while ago. It took several months before my liver enzymes fell into the normal range. After reading the information regarding cholesterol and lethal prostate cancer, I sent an email to my oncologist to ask him if there weren't some other statin I could take that would be a little more agreeable with me. He suggested Livalo but wasn't sure whether my health insurance would pay for it. While it appears that "LIVALO® IS ONLY MINIMALLY METABOLIZED VIA THE CYP450* SYSTEM," it uses another enzyme or pathway that "is in conjugation with glucuronic acid via liver UGTs† with subsequent formation of pitavastatin lactone." However, upon delving deeper, I find that this medication, i.e., side effects and safety, seems no better nor worse than most any other statin. Any Livalo takers out there?