I took someone's advice and called Bayer Corp today. What a waste of one hour. Minimum wage level 1 employee bumbling around trying to get me answers. I already read the entire product packet. It says that Crestor and Lipitor (and other statins) can accumulate and cause problems/side effects. Looks like Lipitor is better, with Nubeqa, than Crestor. However, they list Lipitor as a potential interaction as well. Thus, I researched and saw that Pitavastatin/Livalo does not process through the liver, in the same way as the aforementioned statins. I think they said it is water based as well, which could reduce interactions that are related to Lipitor or Crestor, with Nubeqa.
Does anyone have an opinion or experience with this? Bayer does not have any data on Nubeqa with Livalo, or else they have the data and won't share it with me because they are afraid of some lawsuit down the road. I read a previous post about statins, and some guys liked its effects, and Patrick O'Shea responded poorly to it. This post/question has more to do with taking it with Nubeqa, and not just a specific assessment of statins. Crestor has been good to me for six years, but it's listed as moderate interaction with Nubeqa. I've also asked cardiologists and oncologists about this subject and they don't have an answer, other than "refer to the prescription packet" for answers.
If Livalo is the best option, then would one assume that any of the Livalo dose options would not interact with Nubeqa?
Another interesting thing about Pitivastatin is that it's shown to have some anti- lung cancer effects, which could possibly help fight other types of cancer as well. Here is one article related to that topic -
FWIW - I have no side effects from pitavastatin 4 mg/day. I get it from India to save money, but the new Medicare drug cap of $2,000/yr may change that next year.
thats good news. thanks. I'll see what my cardiologist says about my request for the switch. I did read something about needing to be careful if you have hypothyroidism. My current Free T-4 level is .79, so I'd like to find a safe way of raising that. Apparently, having it too low and taking pitivastatin could cause renal kidney issues of some kind.
Thanks, George. The possible anti-PCa effect seems promising, Did you see the link posted by Bigm789 recently? The Anti-Cancer Effect of Pitavastatin May Be a Drug-Specific Effect:
Good against CVD and possibly PCa, with probably low side effects on top of it. What a substance! Belatedly I understand why statins are so popular on this forum. And Pitavastatin seems to be the best one. Thanks to you and Bigm789 for bringing it up. Now to get hold of it. It´s not even available in my country. It will probably be India.
It's generic. No prescription, but there is a shipping fee and it takes about a month to arrive - so I always put in a large order and order well in advance. I also get my Xarelto from them.
Most US drugs are manufactured in India, so it is probably closer to the source. I've found them to have good quality (at least in effectiveness and no side effects), but I haven't taken them to a lab to be tested. But with the new $2000/yr Medicare drug co-pay limit and negotiation of drug prices, I may get my drugs here eventually.
One can't take crestor, because daro will increase the blood level a lot. I changed Crestor for Lipitor 40 mg and Zetia. My cholesterol is around the 130s, with LDL below 80.
Snuffy Myers switched the statin that I was on (I think it was Lipitor) to Crestor back when I started taking Xtandi a little over 8 years ago. He said Crestor won’t interfere with the Xtandi. Not sure if it’s the same for Nubeqa. I’ve had no issues, cholesterol and LDL numbers have been great. I take 5 mg daily.
Nubeqa says to avoid Cresor and others. I requested Livalo. Simvastatin would be safer than crestor because of the shorter half life, from what I was told. nubeqahcp.com/clinical-info...
Nubeqa/Darolutamide is mainly metabolized by the CYP3A4 hepatic enzyme, but Livalo/Pitavastatin and Crestor/Rosuvastatin are metabolized by CYP2C8, CYP2C9 and CYP2C19 enzymes.
Concomitant administration of Nubeqa increases the plasma concentration of Crestor approximately 5-fold.
Crestor is a substrate of OATP1B1 and OATP1B3 and is mainly taken up into the liver through these transporters, but Nubeqa inhibits these hepatic transporters.
Other OATP1B1 and OATP1B3 substrate drugs can be found in the following links:
Bottom Line - what do you think is the best option for trying to slow the cancer - Livalo and Nubeqa, Simvastatin and Nubeqa, or reduced dose of Crestor and Nubeqa. One article says that daro and simvastatin worked the best on CRPC. Livalo did well at fighting lung cancer but prostate cancer hasn't really been researched I presume.
FYI when I call Bayer for info like you were looking for I immediately ask to speak to one of their pharmacists. Hope that helps in case there are any future inquiries you may need to make
I did that at first but i received one of the rudest people of all time. She also couldn’t help me because i got the drug through my doctors office, and not through the bayer pharmacy. I had some choice words for her before i hung up. She was a true bitch and wouldn’t let me finish a sentence. She was doing it on purpose. Very sad.
My husband starts Darolutamide tomorrow. He is currently on Rosuvastatin tablets 10mg a day. Will that interfere with his Daro or have bad side effects?
Yes... he is... and he starts today! Praying it helps clear up the cancer cells in his bone marrow so he can start chemo (right now he is too anemic). Thanks so much!
My husband is still taking his Rosuvastatin (crestor) every day along with his darolutimide. No side effects and all his blood work looks good. His lipid results before were good, and I'm not sure what they are now. He is having blood work done on Tuesday so I'll ask them to check that and I'll get back to you! Thankfully my husband is doing quite well and we were thankful our doctor put him on the triple therapy because his cancer was very aggressive. I hope you are doing well !!! ❤️
I take Crestor (the generic version Rosuvostatin) with Nubeqa, but because the Nubeqa increases the dose of Crestor, my cardiologist reduced the amount to only 5 mg every other day. No problems so far...
I take Nubeqa and Crestor (the generic version). Since Nubeqa increases the amount of Crestor by about 4 times, my cardiologists reduced me to only 5mg every other day...... so far so good
I take Nubeqa with 5 mg of Crestor daily. My cardiologist added 10 mg of Zetia to make up for the 40 mg of Crestor I was originally on before starting Nubeqa.
Just wondering how the Statin use has been working out for all?
I began Nubeqa last Nov and was already on Crestor. Dropped it to 5mg per day, but the lipids increased. So doctor is thinking to increase it to 10mg per day. I did it and haven't suffered any side effects, ie, the Darolutamide making the Crestor 5x more (effect). I was on 20mg before dropping it to 5mg.
So just looking to revive this thread and get some feedback.
C1, when you switched to 5mg Crestor, did you also add 5 or 10mg of zetia, as well? I changed to 5 mg of Crestor and 10 mg zetia. I’ve been cutting too 7.5 Crestor and 5 mg zetia, every other day and no additional side effects. I haven’t got new lipids test yet. I’m due for that in a few weeks. I think the study showed that Crestor could increase levels by 5x, however, they didn’t say how frequently that happened. It may have only happened in a small % of people it was wrong of them not to report that %. The reason i cut the zetia sometimes odd because a study showed lipid reduction the same (26 vs 25 %) composting 10 mg with 5 mg.
What were your before and after lipids results? All of us need to share our data with each other, using this discussion thread. I hope the other guys are reading this too.
Lastly, i had problems using pitivastatin , with muscle aches and tendon ligament pain and weakness. Then i tried simvastatin and the problem continued, although, i wasn’t on it long enough to vilify simvastatin as well. Crestor and zetia don’t seem to be bothering me.
I'll have to look up the #'s as I don't remember off hand. Definitely interested too if anyone has examined the difference with Hydrophilic vs Lipophilic Statins. Aside from the potential Daro CYP effects...
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