Starting Lynparza

Today I will begin taking Lynparza. It is a PARP inhibitor. Dr. Myers prescribed it after analyzing the results of my recent Guardant360 genetic blood test, which revealed that my prostate cancer has a defective ATM gene. I feel as if I am reaching the outer limits of "normal" treatment, but am excited to start it, as 80% of those on Lynparza achieve a complete remission.

Has anyone else out there taken Lynparza, and if so, what side effects?

Thanks.

8 Replies

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  • Curious as to where you received the 80% remission info?

  • My gene analysis also shows that Olaparib[Lynparza}, is a drug of choice for me against the Mutations found in my 315 Gene Analysis. But at this time I am undetectable as to PSA, thru my 3 Drug ADT Protocol, the same one Dr. Meyers uses, and my extreme supplemental program--but at least I know what has a good chance of stepping on my Pca, if and when it rears its ugly head. By the way is Dr. Meyers a Urologist or Oncologist--seems like he plays both roles!

    Nalakrats

  • Dr.Myers is a Medical Oncologist and a Pharmacologist. Makes me feel more secure since I take 10 prescription drugs!

  • Thanks---good luck with the Olaparib.

    Nalakrats

  • In the past 10 months, I have known 5 men taking olaparib. 2 have lost their fight, for 2 the jury is still out, and one is having much success.

    You may want to check with @BuffaloBill on the UsTOO Inspire site; not only has he had great success with his distant tumors literally melting away, but by profession runs a research lab at Roswell Park (NCCN institution) where he has been researching BRCA pathways and olaparib for many years!

    Alternatively, please join our virtual support group that he frequently attends. The next meeting will be tomorrow, Tuesday, 10/25 at 6pm EDT. For more information on how to participate, please visit http:/ancan.org.

    Onward & upwards, rd

  • Thanks for the info. Will reach out to BuffaloBill.

  • Hi Vandy69

    I have been on Lynparza since April 1st 2016. My PSA has been slowly declining from 3.9 to 1.7 yesterday! Obviously I am thrilled with the trend as long as it lasts. (I have a BRCA2 mutation)

    I have to say though that I find the medication pretty tough. Always exhausted. I have just started with Wisconsin American Ginseng which supposedly will help with cancer related fatigue.

    I am also on Zytiga (now 42 months!) Xgeva, and Firmagon. Off label I take a statin (Crestor), metformin, aspirin and vitamin D3 (10,000 units). I also started with weekly estrogen patches 3 months ago.

    I did Provenge almost 4 years ago and finished 6 months of Xofigo this August.

    Vandy, I cross my fingers that the Lynparza will work for you too.

    Kind regards

    Terje

  • Hi Terje,

    Thank you for the feedback on Lynparza. In my 4+ years, I have had Lupron, Firmagon, Casodex, Zytiga, high dose Ketoconazole, Xtandi, Metformin, Livalo, Leukine, Somatuline, etc. Dr. Myers believes in using multiple drugs at a time, but my current 10 drug mix was not working, so he added Lynparza and Celecoxib and subtracted Xtandi and Ursodiol as well as several supplements. My mets are confined to lymph nodes, but since my prostate gland has come back (never treated initially as I was metastatic at diagnosis), I am headed for proton therapy.

    Cannot wait to see what Lynparza does for me! Keep up the fight.

    Vandy69

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