PCa & Blood fatty acid patterns.

[pjoshea13]

New study below (from the Physicians' Health Study). (OR = odds ratio, i.e. relative risk)

"Fatty acids levels were measured in whole blood samples of 476 cases and their matched controls by age and smoking status."

"Two patterns explaining 40.9 % of total variation in blood fatty acid levels were identified."

"Pattern 1, which mainly reflects polyunsaturated fatty acid metabolism, was suggestively positively related to prostate cancer risk (ORquintile 5 vs. quintile 1 = 1.37"

"Pattern 2, which largely reflects de novo lipogenesis, was significantly associated with higher prostate cancer risk (ORquintile5 vs. quintile1 = 1.63 ..."

"This association was similar across tumor stage, grade, clinical aggressiveness categories and follow-up time."

With pattern 1, too bad that the Abstract gives nothing away regarding omega 3/6.

With pattern 2, no explanation how "higher activity in the de novo lipogenesis pathway was related to higher risk of prostate cancer".

{Higher activity of de novo lipogenesis probably relates to high carbohydrate diets, where excess carbs are converted to triglycerides for storage. Which perhaps implicates the metabolic syndrome?}

-Patrick

ncbi.nlm.nih.gov/pubmed/274...

Cancer Causes Control. 2016 Aug 3. [Epub ahead of print]

Blood fatty acid patterns are associated with prostate cancer risk in a prospective nested case-control study.

Yang M1, Ayuningtyas A2, Kenfield SA2,3, Sesso HD2,4, Campos H1, Ma J5, Stampfer MJ2,5, Chavarro JE6,7,8.

Author information

Abstract

BACKGROUND:

Circulating fatty acids are highly correlated with each other, and analyzing fatty acid patterns could better capture their interactions and their relation to prostate cancer. We aimed to assess the associations between data-derived blood fatty acid patterns and prostate cancer risk.

METHODS:

We conducted a nested case-control study in the Physicians' Health Study. Fatty acids levels were measured in whole blood samples of 476 cases and their matched controls by age and smoking status. Fatty acid patterns were identified using principal component analysis. Conditional logistic regression was used to estimate odds ratio (OR) and 95 % confidence interval (CI).

RESULTS:

Two patterns explaining 40.9 % of total variation in blood fatty acid levels were identified. Pattern 1, which mainly reflects polyunsaturated fatty acid metabolism, was suggestively positively related to prostate cancer risk (ORquintile 5 vs. quintile 1 = 1.37, 95 % CI = 0.91-2.05, P trend = 0.07). Pattern 2, which largely reflects de novo lipogenesis, was significantly associated with higher prostate cancer risk (ORquintile5 vs. quintile1 = 1.63, 95 % CI = 1.04-2.55, P trend = 0.02). This association was similar across tumor stage, grade, clinical aggressiveness categories and follow-up time.

CONCLUSION:

The two patterns of fatty acids we identified were consistent with known interactions between fatty acid intake and metabolism. A pattern suggestive of higher activity in the de novo lipogenesis pathway was related to higher risk of prostate cancer.

KEYWORDS:

Blood fatty acids; Case–control study; Principal component analysis; Prostate cancer

PMID: 27488836 DOI: 10.1007/s10552-016-0794-6

[PubMed - as supplied by publisher]

[chascri]

So a high carb diet is bad? Does it follow that a low carb diet is good?

[pjoshea13 in reply to chascri]

Well, Dr. Myers has argued forcefully against a high-carb/low-fat diet with PCa. I wouldn't say that the Mediterranean diet (whatever that means) that he favors, is low-carb, but it certainly isn't low-fat. It's a middle-of-the-road option that should appeal to many.

There are some PCa papers on low-carb diets, & I can easily summarize them in a new post this morning.

-Patrick