Another study in coffee intake and its association with lower PCa risk. It does NOT address post-diagnosis correlations, however. There's a good discussion on the limitations of the study, and reasonable explanation on what statistical methods they used to investigate their influence. Looks to me they looked into 0-10 "cups" per day range of consumption, and the linear relationship worked.
"Results Sixteen prospective cohort studies were finally included, with 57 732 cases of prostate cancer and 1 081 586 total cohort members. Higher coffee consumption was significantly associated with a lower risk of prostate cancer. Compared with the lowest category of coffee consumption, the pooled relative risk (RR) was 0.91 (95% CI 0.84 to 0.98), I2= 53.2%) for the highest category of coffee consumption. There was a significant linear trend for the association (p=0.006 for linear trend), with a pooled RR of 0.988 (95% CI 0.981 to 0.995) for each increment of one cup of coffee per day. For localised, advanced and fatal prostate cancer, the pooled RRs were 0.93 (95% CI 0.87 to 0.99), 0.88 (95% CI 0.71 to 1.09) and 0.84 (95% CI 0.66 to 1.08), respectively. No evidence of publication bias was indicated in this meta-analysis."
Glad to see your back at the keyboard. j-o-h-n shutdown 81 Kitchen on the corner of 86 and Lexington. But Monte and I quickly reopened M&X Hudson River Sushi and Hibachi Bar and Grill. A great success so far. The Hudson Carp is a favorite. We reuse the hypodermic needles as chop sticks. We don't serve ice cream so j-o-h-n hasn't come in yet.
Yea I’ve got a footprint the size of one of j-o-h-n ‘s shoes from his clown suit ... where the Zometa kicked my a$$....but I’m back once again a little ruffled and fuzzy around the edges but ready for another one. yayahahahaya yayahahahaya. ( thank you, may I have another )
Yea ...yea ... I can see that ! Use those little plastic baggies to hold the sushi slices or bones you pick out of your throat from the carp. Hypodermic chopsticks / olive spears... sole ( old shoe )or threadbare tire soup.
Mannnnnnn ... I think you’ve got a going Jessie there.
I’m surprised that j-o-h-n hasn’t been in there yet ... surely he’ll be in there soon. He might be staying in due to coronavirus tho.
I actually took time off from panhandling and walked over to 86 and Lex. When I passed the M&X ShoeShe and Hibitchi Bar/Grill there was a sign on the door which read "City of New York, Board of Health, Closed until further Notice". So don't fret I'll be there when you re-open... But since I'm bringing Dolly with me, please replace those needle chopsticks with the "Single Color Chenille Stems/Pipe Cleaners".... Thanks guys....
I once joked that there were now more meta-analysis PCa/coffee studies (~20) than original studies. So it was inevitable that someone would do an "umbrella" review of the former (2017).
"To evaluate the associations between coffee and caffeine consumption and various health outcomes, we performed an umbrella review of the evidence from meta-analyses of observational studies and randomized controlled trials (RCTs). Of the 59 unique outcomes examined in the selected 112 meta-analyses of observational studies, coffee was associated with a probable decreased risk of breast, colorectal, colon, endometrial, and prostate cancers; cardiovascular disease and mortality; Parkinson's disease; and type-2 diabetes. Of the 14 unique outcomes examined in the 20 selected meta-analyses of observational studies, caffeine was associated with a probable decreased risk of Parkinson's disease and type-2 diabetes and an increased risk of pregnancy loss. Of the 12 unique acute outcomes examined in the selected 9 meta-analyses of RCTs, coffee was associated with a rise in serum lipids, but this result was affected by significant heterogeneity, and caffeine was associated with a rise in blood pressure. Given the spectrum of conditions studied and the robustness of many of the results, these findings indicate that coffee can be part of a healthful diet." [1]
It seems repetitive, but it's always good to have fresh set of eyes re-evaluate these findings with (sometimes) different statistical tools and bends. My issue with the coffee studies has been the definition of the "cup". There's just an enormous number of possible permutations between the size (L,M,S), density (espresso, diluted diner coffee) and roast. But I do stick with 4 cups (8 oz) of very dark roast/espresso a day.
The most convincing study, IMO, involved Italian espresso drinkers. Seemed to back up my belief that study results are often diluted by including those who drink milky coffee. The casein binds & inactivates the polyphenols.
I use 2 heaped scoops (a rounded third of a cup) of beans for my cup of Aeropress coffee. Just a splash of milk. I only drink 2 of those daily.
I have had lunches with Nalakrats where he drinks a pot of coffee before looking at the menu & another pot after the meal.
Another variable is the filter. Mine is metal, not paper, so I get oils (might be good or bad.)
Of course, we must wait for the advanced PCa intervention study before we can know for sure what the effects on survival are. lol
I've always said that, like sodium chloride, coffee is a miracle drug. I even eat dark chocolate-covered coffee beans, delicious. Never mind my G10 diagnosis. This is my story, and I'm sticking to it.
The drug APC, aspirin, phenacetin and caffeine! It was found that the caffeine magnified the pain reducing effects of the drugs. There isn't much money in caffeine but a cup of percolated, organic, black coffee is an effective and --pleasurable way to spend a few minutes after taking a NSAID.
The FDA took all drugs containing phenacetin off the market in 1983. the reasons--kidney failure and carcinogen.
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