At the age of 49 in October of 2013, I had a prostatectomy with 23 nodes taken. I am a gleason 4+5, SVI in both sv's, epe, negative margins, LN0. Decipher test results 25%. I belong to the club I never wanted to join of high risk locally advanced Pca. No erectile dysfunction and 98% urinary continence, with an occasional squirt with a sneeze. All sounds great so far. 3 mos. after surgery psa 0.00 until my psa rose to 0.1 in 11/15 and 0.157 in May of 2016. It won't be long now and it will be classified as a biochemical recurrence. I just talked with rad. oncologist today to pursue salvage radiation of prostate bed and pelvic area. He suggested a course of Casodex for 4 mos with radiation and 28 months of Lupron. No Dx or node involvement at this time. I am not interested in the 28 months of Lupron now, I most likely will have time for that later. But I am considering the 4 months of Casodex with the radiation. I am sold on radiation but not ADT at this time. Have any of you had a short 3-4 month course of Casodex? If so did you have breast enlargement, swelling and tenderness as a side effect? I am in great shape run 25+ miles a week and run half marathons as well as other races every year. I have to think my excercise regime and extremely healthy eating will keep some of these side effects at bay?