It has been 3 years since my diagnosis. Beginning PSA was 843 and Gleason was 4+5. Began with Lupron and Casodex. PSA declined to 78, but began rising again shortly. Tried degerilix briefly without success, then shifted to Zytiga for sever months. Progression slowed and PSA stabilized around 270. Moved on the Xtandi which worked awhile, but progression resumed in May 2015, so we moved on to docetaxel. Only side effect was low white blood cell count during first cycle. That was resolved by addition of Neulasta. After 10 cycles took a break for over 3 months (probably too long). First pain in lower back began in February, controlled with Advil. Restarted docetaxel last week since I reacted so well, but we will reevaluate after 3 cycles. Considering 3 next steps. Current PSA is 1467, but as my doctor says that is only a number to be considered in conjunction with how I feel and what scans show. I practice qigong several times a week, remain active and have a positive attitude in the face of these challenges.