Hi, I have had a nasal ulcer for the past two years that just will not heal despite antibiotics and steroid spray. I have tried the Neil Med sinus rinse and find it irritates my sinuses rather than helps. I had a few respiratory issues at the beginning of last year and suffer with what I believe to be TMj and have sporadic pain under my chin and recently I have been suffering with headaches. I quite often have a very bizarre feeling in my hands during sleep which I can only describe feels like my hands are on a roller coaster.........strange I know! And it wakes me up. Had strange little bruises pop up and disappear but isolated and normally hands or feet. Anyway sorry for rambling! I saw an ENT consultant at Addenbrooke’s Hospital last week who thinks it could be GPA but after researching although I have a few symptoms I don’t have them to the degree that I feel I would have should it be GPA. I also have Rheumatoid Arthritis but it doesn’t present typically either and I also have roving pain that moves from joint to joint. Does this sound familiar to anyone? And can anyone tell me what to expect with a nasal biopsy? Is in generally done under local anaesthetic? Thank you for reading!