If you have Hypocomplementemic Urticarial Vasculitis Syndrome and you have tried many medications Methatrexate IM and/or PO, immurane, cytoxin, cellcept, Plaquinel, Dapsone without favorable results. Ask your doctor to try Rituxan. It took two doses 1 month apart and I have been spot free now for 4 years. But I did have HUVS for almost 15 years before they diagnosed it so there is quite a bit of damage including skin, bones, joints, and especially lungs. But I am doing well. Drive myself, shop, clean house. I am just very slow.
Hope this helps anyone. HUVS is so rare and unusual that there is just not a standard treatment yet. And I think it can be caused by many different things so it will be hard and take time. The Mayo clinic was able to confirm the spots internal and external even the soles of my feet and palms of my hands.
Write if you have any questions. I hope this medicine will work for some of you that are still having problems. It is very expensive, but there are grants and your doctor will know how to apply for them. I was able to get a grant for both of my does and only ended up paying about $100.00 American each dose.
I was so glad it was spots. It was easier to coordinate my wardrobe with spots rather than stripes. You have to laugh.
Thank you for letting me share my story and I sincerely hope it helps.