I usually take my pitiful dose of levo in the morning. I know its not enough as I'm having a flare up of symptoms and everything is unsettled again. Latest bloods clearly show I'm now undermedicated. My body does seem to respond well to levo. Last night, my cramps were keeping me awake, so I took an extra 25 levo and within an hour, the cramps had eased. My late night top-up of levo seemed to help my muscle cramps - do others take night-time top-ups and does it help?