High TSH result but well medicated: Hi there... - Thyroid UK

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High TSH result but well medicated

Needlehaystax profile image
13 Replies

Hi there,

I have been on 125mcg of Levo for a year now (I am hypo with hashimotos) which kept my TSH below 1 for a long time. It has now shot up to 6.75 which is officially subclinical again. My T3 is in range but low and my T4 optimal.

tsh: 6.75mIU/l (0.35-5.5)

ft3: 2.41pmol/l (2.26 - 5.63)

ft4: 18.81 pmol/l (11.9-21.6)

What does this mean now for me? Do I need to up the meds yet again? How can avoid this? Or do I need T3 meds? Really depressing seeing as Ive been seeing functional doctors, lifestyle medicine doctors and nobody seems to get me anywhere even though I'm trying everything no gluten, dairy, antiinflam diet and exercise etc etc.

Thanks for your help in advance

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Needlehaystax profile image
Needlehaystax
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13 Replies
SlowDragon profile image
SlowDragonAmbassador

Free T4 (fT4) 18.81 pmol/L (11.9 - 21.6) 71.2%

Free T3 (fT3) 2.41 pmol/L (2.26 - 5.63) 4.5%

Ft3 very very low

was test early morning and last dose levothyroxine 24 hours before testing

Which brand of levothyroxine are you taking

Do you always get same brand

When were vitamin D, folate, ferritin and B12 last tested

Exactly what vitamin supplements are you taking

Needlehaystax profile image
Needlehaystax in reply toSlowDragon

test was 7:30am no food or levothyroxine and last dose 24hrs before. Was on mixed brands but this month I switched to full teva for both doses but I thought that would be better? I was on Teva and accord before when TSH below 2. Just had all the bio markers you mentioned tested last week and all in range.

I stopped vitamins for the 2weeks before my test last week, as didn’t want them interfering with my results but I have historically been taking:

Probiotic

Bcomplex drops high dose

Vitamin D high dose

Glutathione drops

coq10,

omega3,

Ferrous fumerate

Vit C

Cordyseps

Curcumin

Blackseed oil

Selenium

Ashwaganda

Zinc

Magnesium

Myoinisitol

I had bloods in October and T3 was still low but my TSH was around the 3 mark so shocked it’s suddenly shot up.

Needlehaystax profile image
Needlehaystax in reply toNeedlehaystax

I meant B complex not just b12 alone which obviously contains folic acid

helvella profile image
helvellaAdministrator in reply toNeedlehaystax

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SlowDragon profile image
SlowDragonAmbassador in reply toNeedlehaystax

Teva brand upsets many people as it contains mannitol

You could try Vencamil

Vencamil is lactose free and mannitol free. originally only available as 100mcg only, but 25mcg, 50mcg and 75mcg tablets became available Sept 2024

Prior to March 2023 Vencamil was called Aristo

Vencamil often very well tolerated/best option for many people

How to get Vencamil stocked at your local pharmacy

healthunlocked.com/thyroidu...

Posts discussing Vencamil

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu....

Just had all the bio markers you mentioned tested last week and all in range.

Please add results for vitamin D, folate, ferritin and B12

Why are you taking ashwagandha

have you tested cortisol levels ever

Or retested recently

regeneruslabs.com/products/...

portal-app.inspira-regeneru...

You only need to stop B complex and iron supplements 5-7 days before testing

In week before blood test, when you stop vitamin B complex, you might want to consider taking a separate folate supplement (eg Jarrow methyl folate 400mcg)

Needlehaystax profile image
Needlehaystax in reply toSlowDragon

thanks so much I had no idea about that. So do you think that my Teva could have actually raised my TSH ? If so mind blown that something that is meant to control my condition worsens it 🤯

Needlehaystax profile image
Needlehaystax in reply toSlowDragon

also I’m taking ashwaganda purely because a functional doctor, a functional nutritionist and naturopath told me to take it to balance hormones. I had a DUTCH hormone test and my adrenals are shot to peices. I have low cortisol esp in the mornings which apparently signals stage 3/4 adrenal fatigue where they don’t work brilliantly. I also have sky high prolactin but not sure what that means. I think I was advised to take ashwaganda as part of my adrenal/hormone health - is there evidence that I should stop ashwaganda in my situ? I have heard mixed things.

All my bio markers I’ll send separately - sorry in advance for messages!

Needlehaystax profile image
Needlehaystax in reply toSlowDragon

here are some grabs of my bio markers

Needlehaystax profile image
Needlehaystax in reply toSlowDragon

couldn’t add grabs :

Vit d 73nmol 49-375

B12 360ngl 197-771

folic acid 8.5 ug/l 3.0-26.8

ferritin 60.12 ug/l 10-120

SlowDragon profile image
SlowDragonAmbassador in reply toNeedlehaystax

So all these vitamin levels are a bit low

But you stopped supplementing 2 weeks before test ….too long

B12 low and this doesn’t drop fast when stop supplements

So you likely need daily separate B12 as well as daily vitamin B complex

With serum B12 result below 500, (Or active B12 below 70) recommended to be taking a separate B12 supplement

Then once your serum B12 is over 500 (or Active B12 level has reached 70), you may be able to reduce then stop the B12 and just carry on with the B Complex.

If Vegetarian or vegan likely to need ongoing separate B12 few times a week

Highly effective B12 drops

natureprovides.com/products...

Or

B12 sublingual lozenges

uk.iherb.com/pr/jarrow-form...

cytoplan.co.uk/shop-by-prod...

In-depth article on different forms of B12

perniciousanemia.org/b12/fo...

B12 range in U.K. is too wide

Interesting that in this research B12 below 400 is considered inadequate

healthunlocked.com/thyroidu...

perniciousanemia.org/b12/le...

And why aiming to keep B12 over 500 recommended

perniciousanemia.org/b12/le...

Great reply by @humanbean on B12 here

healthunlocked.com/thyroidu...

Low folate

supplementing a good quality daily vitamin B complex, one with folate in (not folic acid)

This can help keep all B vitamins in balance and will help improve B12 levels too

Difference between folate and folic acid

healthline.com/nutrition/fo...

B vitamins best taken after breakfast

Igennus B complex popular option. Nice small tablets. Most people only find they need one per day. But a few people find it’s not high enough dose and may need separate methyl folate couple times a week

Post discussing different B complex

healthunlocked.com/thyroidu...

Thorne Basic B recommended vitamin B complex that contains folate, but they are large capsules. (You can tip powder out if can’t swallow capsule) Thorne can be difficult to find at reasonable price, should be around £20-£25. iherb.com often have in stock. Or try ebay

IMPORTANT......If you are taking vitamin B complex, or any supplements containing biotin, remember to stop these 5-7 days before ALL BLOOD TESTS , as biotin can falsely affect test results

endo.confex.com/endo/2016en...

endocrinenews.endocrine.org...

In week before blood test, when you stop vitamin B complex, you might want to consider taking a separate folate supplement (eg Jarrow methyl folate 400mcg) and continue B12 until serum B12 over 500

SlowDragon profile image
SlowDragonAmbassador in reply toNeedlehaystax

How much vitamin D are you taking

Ferritin

Look at increasing iron rich foods in diet

DippyDame profile image
DippyDame

When you have Hashi's your hormone levels will fluctuate from time to time as follows...

An underactive thyroid often occurs when the immune system, which usually fights infection, attacks the thyroid gland. This damages the thyroid, which means it's not able to make enough of the hormone thyroxine, leading to the symptoms of an underactive thyroid.

A condition called Hashimoto's disease is the most common type of autoimmune reaction that causes an underactive thyroid.

It's not clear what causes Hashimoto's disease, but it runs in families. It's also common in people with another immune system disorder, such as type 1 diabetes and vitiligo. Ex NHS

How do you feel?

Symptoms are an important part of any thyroid diagnosis when numbers are confusing. TSH is not a reliable marker so don't be led up the garden path by that.

I suspect your T4 to T3 conversion is impaired (high FT4 with low FT3) causing the low FT3. You may need T3

You could try increasing levo to 150mcg, you have just enough room to do this, though I doubt it would make much difference. Avoid FT4 becoming over range that can have other negative health implications

Suggest you book an appointment with an endocrinologist, rather than lifestyle medicine doctors, with a view to initiating T3 treatment

Weight gain can occur when FT3 is low, T3 regulates the metabolism and if T3 is low then metabolism runs slow which doesn't burn up the calories....weight gain follows

Sorry but I don't think you are, "well medicated"

Needlehaystax profile image
Needlehaystax in reply toDippyDame

thanks very much - I’ll do that and book an appointment

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