Hypothyrodisim and Low White Blood Cells - Thyroid UK

Thyroid UK

141,181 members166,422 posts

Hypothyrodisim and Low White Blood Cells

PorridgeFanatic profile image
8 Replies

Hello

Diagnosed Hypothyroidism one year ago and have "levelled" on 50mg Levothyroxine TEVA brand. Fluctuating symptoms ongoing, although definitely an improvement from one year ago.

My neutrophils and lymphocytes are too low, and fluctuate within the too-low range, with bloods every 6 months. This was a feature pre-diagnosis too. Does anyone know if this is a feature of Hypothyroidism in some way or for any reason?

My GP seems puzzled and the hematologist recommends 6 monthly bloods and referral if my mouth becomes sore.

Any light on the subject welcome, in relation to Hypo.

Many thanks

Written by
PorridgeFanatic profile image
PorridgeFanatic
To view profiles and participate in discussions please or .
Read more about...
8 Replies
SlowDragon profile image
SlowDragonAdministrator

50mcg Levo is only the standard STARTER Dose

You are likely not on high enough dose

Please add most recent thyroid and vitamin results and ranges

You are legally entitled to printed copies of your blood test results and ranges.

Just testing TSH is completely inadequate

For full Thyroid evaluation you need TSH, FT4 and FT3 tested

Also both TPO and TG thyroid antibodies tested at least once to see if your hypothyroidism is autoimmune

Very important to test vitamin D, folate, ferritin and B12 at least once year minimum

Low vitamin levels are extremely common when hypothyroid, especially with autoimmune thyroid disease

About 90% of primary hypothyroidism is autoimmune thyroid disease, usually diagnosed by high TPO and/or high TG thyroid antibodies

Autoimmune thyroid disease with goitre is Hashimoto’s

Autoimmune thyroid disease without goitre is Ord’s thyroiditis.

Both are autoimmune and generally called Hashimoto’s.

Significant minority of Hashimoto’s patients only have high TG antibodies (thyroglobulin)

20% of autoimmune thyroid patients never have high thyroid antibodies and ultrasound scan of thyroid can get diagnosis

In U.K. medics hardly ever refer to autoimmune thyroid disease as Hashimoto’s (or Ord’s thyroiditis)

Essential to test vitamin D, folate, ferritin and B12

Lower vitamin levels more common as we get older

For good conversion of Ft4 (levothyroxine) to Ft3 (active hormone) we must maintain GOOD vitamin levels

What vitamin supplements are you taking

VERY important to test TSH, Ft4 and Ft3 together

What is reason for your hypothyroidism

Autoimmune?

Recommended that all thyroid blood tests early morning, ideally just before 9am, only drink water between waking and test and last dose levothyroxine 24 hours before test

This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip)

Private tests are available as NHS currently rarely tests Ft3 or all relevant vitamins

Post all about what time of day to test

healthunlocked.com/thyroidu...

Testing options and includes money off codes for private testing

thyroiduk.org/testing/

Medichecks Thyroid plus BOTH TPO and TG antibodies and vitamins

medichecks.com/products/adv...

Blue Horizon Thyroid Premium Gold includes BOTH TPO and TG antibodies, cortisol and vitamins

bluehorizonbloodtests.co.uk...

Medichecks and BH also offer private blood draw at clinic near you, or private nurse to your own home…..for an extra fee

Only do private testing early Monday or Tuesday morning.

Tips on how to do DIY finger prick test

support.medichecks.com/hc/e...

SlowDragon profile image
SlowDragonAdministrator

Levo doesn’t “top up” your own thyroid output, it replaces it

Most important results are ALWAYS Ft3, followed by Ft4 and GOOD vitamin levels

Always test early morning and last dose Levo 24 hours before test

Guidelines of dose Levo by weight

approx how much do you weigh in kilo

Even if we frequently start on only 50mcg, most people need to increase levothyroxine dose slowly upwards in 25mcg steps (retesting 6-8 weeks after each increase) until eventually on, or somewhere near full replacement dose (typically 1.6mcg levothyroxine per kilo of your weight per day)

cks.nice.org.uk/topics/hypo...

bnf.nice.org.uk/drugs/levot...

nhs.uk/medicines/levothyrox...

Adults usually start with a dose between 50 micrograms and 100 micrograms taken once a day. This may be increased gradually over a few weeks to between 100 micrograms and 200 micrograms taken once a day.

Some people need a bit less than guidelines, some a bit more

TSH should be under 2 as an absolute maximum when on levothyroxine

gponline.com/endocrinology-...

Graph showing median TSH in healthy population is 1-1.5

web.archive.org/web/2004060...

Comprehensive list of references for needing LOW TSH on levothyroxine

healthunlocked.com/thyroidu....

onlinelibrary.wiley.com/doi...

If symptoms of hypothyroidism persist despite normalisation of TSH, the dose of levothyroxine can be titrated further to place the TSH in the lower part of the reference range or even slightly below (i.e., TSH: 0.1–2.0 mU/L), but avoiding TSH < 0.1 mU/L. Use of alternate day dosing of different levothyroxine strengths may be needed to achieve this (e.g., 100 mcg for 4 days; 125 mcg for 3 days weekly).

sciencedirect.com/science/a...

The optimal daily dose in overt hypothyroidism is 1·5–1·8 μg per kg of bodyweight, rounded to the nearest 25 μg

SlowDragon profile image
SlowDragonAdministrator

low lymphocytes

bmcpulmmed.biomedcentral.co....

Many previous studies have confirmed the close association between lymphocytes and hypothyroidism [9, 11]. Lymphocytes are involved in the process of hypothyroidism, especially in autoimmune diseases of the thyroid, such as Hashimoto's thyroiditis.

Low neutrophils also linked to being hypo

SlowDragon profile image
SlowDragonAdministrator

By the way it’s 50mcg …….not 50mg

nurse.com/nursing-resources....

Microgram (mcg):

One microgram is one-millionth of a gram

(1 mcg = 0.000001 grams).

Milligram (mg):

One milligram is one-thousandth of a gram

(1 mg = 0.001 grams).

The relationship between micrograms and milligrams is straightforward: 1 milligram (mg) = 1,000 micrograms (mcg).

Levothyroxine content is a very small amount of each tablet

PorridgeFanatic profile image
PorridgeFanatic in reply toSlowDragon

Thank you Slow Dragon. I will look into the detail of your helpful replies and try to get a copy of my latest bloods.

PorridgeFanatic profile image
PorridgeFanatic

Thank you Slow Dragon. I will look into the detail of your helpful replies and try to get a copy of my latest bloods.

Blackcake profile image
Blackcake

Oh sorry I also have the low white blood cells and it makes you feel so weak as if you are anaemic. I was told my WBC is good but tbat is low and to continue taking the iron pills. So strange. I asked the doctor what causes that and he said maybe some type of infection, but he couldn't identify it. I don't what to say, except that I hace noticed thst our diet and surroundings have a lot to do with how we feel.

PorridgeFanatic profile image
PorridgeFanatic in reply toBlackcake

Thank you blackcake, I appreciate your response ... I too feel "anaemic" although my iron levels show within the normal range on bloods. All very strange.

Not what you're looking for?

You may also like...

Low white blood cells?

Hi everyone, I hope that everyone is reasonably well today and that you have a lovely weekend. I...
Castlepoint profile image

Low temperature causing low white blood cell count?

Have been diagnosed with hypothyroidism (Hashimoto's) and neutropenia. Feeling unwell again...
MacG profile image

Dizziness and low blood pressure

Hello all, For the past two weeks I have been experiencing recurrent symptoms of dizziness caused...

Low white blood cell count

Hello, I had a blood test on Monday due to having experienced an episode of fast heart rate & chest...
Smorzando profile image

T4 and blood results after 6 weeks

Finally managed to get my GP to prescribe Eltroxin. wanted to start me on 25mg but I persuaded him...
annabhaird profile image

Moderation team

See all
PurpleNails profile image
PurpleNailsAdministrator
Jaydee1507 profile image
Jaydee1507Administrator
SlowDragon profile image
SlowDragonAdministrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.